The nervous system regulates tissue stem and precursor populations throughout life.
Parallel to roles in development, the nervous system is emerging as a critical regulator of …

Cancer is a major cause of global mortality, both in affluent countries and increasingly in
develo** nations. Many patients with cancer experience reduced life expectancy and …

Neural–tumor interactions drive glioma growth as evidenced in preclinical models, but
clinical validation is limited. We present an epigenetically defined neural signature of …

The tumour microenvironment plays an essential role in malignancy, and neurons have
emerged as a key component of the tumour microenvironment that promotes tumourigenesis …

Gliomas are a diverse group of primary central nervous system tumors that affect both
children and adults. Recent studies have revealed a dynamic cross talk that occurs between …

Glioblastoma, the most aggressive primary brain cancer, has a dismal prognosis, yet
systemic treatment is limited to DNA-alkylating chemotherapies. New therapeutic strategies …

The leptomeninges, the cerebrospinal-fluid-filled tissues surrounding the central nervous
system, play host to various pathologies including infection, neuroinflammation and …

The role of the nervous system in the regulation of cancer is increasingly appreciated. In
gliomas, neuronal activity drives tumour progression through paracrine signalling factors …

The adaptability of glioblastoma (GBM) cells, encouraged by complex interactions with the
tumour microenvironment (TME), currently renders GBM an incurable cancer. Despite …

The evolutionary trajectory of glioblastoma (GBM) is a multifaceted biological process that
extends beyond genetic alterations alone. Here, we perform an integrative proteogenomic …