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The good, the bad, and the opportunities of the complement system in neurodegenerative disease
The complement cascade is a critical effector mechanism of the innate immune system that
contributes to the rapid clearance of pathogens and dead or dying cells, as well as …
contributes to the rapid clearance of pathogens and dead or dying cells, as well as …
Orally absorbed cyclic peptides
Peptides and proteins are not orally bioavailable in mammals, although a few peptides are
intestinally absorbed in small amounts. Polypeptides are generally too large and polar to …
intestinally absorbed in small amounts. Polypeptides are generally too large and polar to …
Roles of neutrophil granule proteins in orchestrating inflammation and immunity
Neutrophil granulocytes form the first line of host defense against invading pathogens and
tissue injury. They are rapidly recruited from the blood to the affected sites, where they …
tissue injury. They are rapidly recruited from the blood to the affected sites, where they …
[HTML][HTML] Systemic delivery of peptides by the oral route: Formulation and medicinal chemistry approaches
In its 33 years, ADDR has published regularly on the po5tential of oral delivery of biologics
especially peptides and proteins. In the intervening period, analysis of the preclinical and …
especially peptides and proteins. In the intervening period, analysis of the preclinical and …
Complement and its role in innate and adaptive immune responses
JR Dunkelberger, WC Song - Cell research, 2010 - nature.com
The complement system plays a crucial role in the innate defense against common
pathogens. Activation of complement leads to robust and efficient proteolytic cascades …
pathogens. Activation of complement leads to robust and efficient proteolytic cascades …
Constraining cyclic peptides to mimic protein structure motifs
Many proteins exert their biological activities through small exposed surface regions called
epitopes that are folded peptides of well‐defined three‐dimensional structures. Short …
epitopes that are folded peptides of well‐defined three‐dimensional structures. Short …
Complement and the regulation of T cell responses
The complement system is an evolutionarily ancient key component of innate immunity
required for the detection and removal of invading pathogens. It was discovered more than …
required for the detection and removal of invading pathogens. It was discovered more than …
[HTML][HTML] Molecular basis of anaphylatoxin binding, activation, and signaling bias at complement receptors
The complement system is a critical part of our innate immune response, and the terminal
products of this cascade, anaphylatoxins C3a and C5a, exert their physiological and …
products of this cascade, anaphylatoxins C3a and C5a, exert their physiological and …
The role of the anaphylatoxins in health and disease
A Klos, AJ Tenner, KO Johswich, RR Ager, ES Reis… - Molecular …, 2009 - Elsevier
The anaphylatoxin (AT) C3a, C5a and C5a-desArg are generally considered pro-
inflammatory polypeptides generated after proteolytic cleavage of C3 and C5 in response to …
inflammatory polypeptides generated after proteolytic cleavage of C3 and C5 in response to …
Modulation of the antitumor immune response by complement
The involvement of complement-activation products in promoting tumor growth has not yet
been recognized. Here we show that the generation of complement C5a in a tumor …
been recognized. Here we show that the generation of complement C5a in a tumor …