Sphingolipids, including the two central bioactive lipids ceramide and sphingosine-1-
phosphate (S1P), have opposing roles in regulating cancer cell death and survival …

Much has been made about JLW Thudichum's colorful, and one could say clairvoyant,
naming of sphingosine “in commemoration of the many enigmas which it presented to the …

One crucial barrier to progress in the treatment of cancer has been the inability to control the
balance between cell proliferation and apoptosis: enter ceramide. Discoveries over the past …

Large granular lymphocyte (LGL) leukemia has been recognized by the World Health
Organization classifications amongst mature T-cell and natural killer (NK) cell neoplasms …

Different mechanisms in cancer cells become resistant to one or more chemotherapeutics is
known as multidrug resistance (MDR) which hinders chemotherapy efficacy. Potential …

Ceramides are a class of sphingolipids which are implicated in skin disorders, obesity, and
other metabolic diseases. As a class with pleiotropic effects, recent efforts have centred on …

Background & Aims Ceramide, a sphingolipid metabolite, affects T-cell signaling, induces
apoptosis of cancer cells, and slows tumor growth in mice. However, it has not been used as …

Sphingolipids are an extensive class of lipids with different functions in the cell, ranging from
proliferation to cell death. Sphingolipids are modified in multiple cancers and are …

Squamous cell carcinoma (SCC) is the most common cancer worldwide. The treatment of
locally advanced disease generally requires various combinations of radiotherapy, surgery …

The sphingolipid family of lipids modulate several cellular processes, including proliferation,
cell cycle regulation, inflammatory signaling pathways, and cell death. Several members of …