Multifunctional nanoparticle-mediated combining therapy for human diseases

X Li, X Peng, M Zoulikha, GF Boafo, KT Magar… - Signal transduction and …, 2024 - nature.com
Combining existing drug therapy is essential in develo** new therapeutic agents in
disease prevention and treatment. In preclinical investigations, combined effect of certain …

Applications of π-π stacking interactions in the design of drug-delivery systems

WR Zhuang, Y Wang, PF Cui, L **ng, J Lee… - Journal of controlled …, 2019 - Elsevier
Noncovalent forces are of considerable importance in the formation of self-assembled drug-
delivery systems. In addition to non-destructively linking the delivery vehicle and guest drug …

Molecular bottlebrush prodrugs as mono-and triplex combination therapies for multiple myeloma

A Detappe, HVT Nguyen, Y Jiang, MP Agius… - Nature …, 2023 - nature.com
Cancer therapies often have narrow therapeutic indexes and involve potentially suboptimal
combinations due to the dissimilar physical properties of drug molecules. Nanomedicine …

Traditional herbal medicine and nanomedicine: Converging disciplines to improve therapeutic efficacy and human health

J Zhang, K Hu, L Di, P Wang, Z Liu, J Zhang… - Advanced drug delivery …, 2021 - Elsevier
Traditional herbal medicine (THM), an ancient science, is a gift from nature. For thousands of
years, it has helped humans fight diseases and protect life, health, and reproduction …

[HTML][HTML] Functionalized niosomes as a smart delivery device in cancer and fungal infection

P Aparajay, A Dev - European Journal of Pharmaceutical Sciences, 2022 - Elsevier
Various diseases remain untreated due to lack of suitable therapeutic moiety or a suitable
drug delivery device, especially where toxicities and side effects are the primary reason for …

Phase‐change materials for controlled release and related applications

J Qiu, D Huo, Y **a - Advanced Materials, 2020 - Wiley Online Library
Phase‐change materials (PCMs) have emerged as a novel class of thermo‐responsive
materials for controlled release, where the payloads encapsulated in a solid matrix are …

Metformin-induced stromal depletion to enhance the penetration of gemcitabine-loaded magnetic nanoparticles for pancreatic cancer targeted therapy

H Han, Y Hou, X Chen, P Zhang, M Kang… - Journal of the …, 2020 - ACS Publications
Pancreatic ductal adenocarcinoma, as one of the most aggressive cancers, is characterized
by rich desmoplastic stroma that forms a physical barrier for anticancer drugs. To address …

Nanoparticles-encapsulated polymeric microneedles for transdermal drug delivery

M Chen, G Quan, Y Sun, D Yang, X Pan… - Journal of Controlled …, 2020 - Elsevier
Polymeric microneedles (MNs) have been leveraged as a novel transdermal drug delivery
platform for effective drug permeation, which were widely used in the treatment of various …

Construction of flexible‐on‐rigid hybrid‐phase metal–organic frameworks for controllable multi‐drug delivery

XG Wang, L Xu, MJ Li, XZ Zhang - … Chemie International Edition, 2020 - Wiley Online Library
Multi‐component MOFs contain multiple sets of unique and hierarchical pores, with different
functions for different applications, distributed in their inter‐linked domains. Herein, we …

Multifunctional lipid bilayer nanocarriers for cancer immunotherapy in heterogeneous tumor microenvironments, combining immunogenic cell death stimuli with …

AE Nel, KC Mei, YP Liao, X Liu - ACS nano, 2022 - ACS Publications
In addition to the contribution of cancer cells, the solid tumor microenvironment (TME) has a
critical role in determining tumor expansion, antitumor immunity, and the response to …