Analyses of steroid receptors are important for understanding molecular details of
transcriptional control, as well as providing insight as to how an individual transacting factor …

Activator protein-1 (AP-1) was first identified as a transcriptional factor that binds to an
essential cis-ele-ment of the human metallothionein lla (hMTIla) promoter [1]. AP-1 is …

Gene regulation by steroid hormones has been a traditional field of research for biochemical
endocrinology since the discovery of puff induction by ecdysone in giant chromosomes of …

Identification of complementary DNAs encoding the human glucocorticoid receptor predicts
two protein forms, of 777 (α) and 742 (β) amino acids, which differ at their carboxy termini …

The promoter regions of several phorbol diester-(TPA-) inducible genes (collagenase,
stromelysin, hMT IIA, and SV40) share a conserved 9 bp motif. Synthetic copies of these …

▪ Abstract Metallothioneins (MT) are low-molecular-weight, cysteine-rich, metal-binding
proteins. MT genes are readily induced by various physiologic and toxicologic stimuli …

I. Introduction M ALE accessory sex glands such as the prostate, seminal vesicle, and
bulbourethral gland have served in various capacities as models for investigating the action …

Alzheimer's disease (AD) 1− 3 is the most common form of dementia (estimated∼ 50− 60%
of all cases), associated with loss of memory (in particular episodic memory), cognitive …

Giucocorticoids are potent inhibitors of coiiagenase induction by phorbol esters and
inflammatory mediators. The target for this negatlve effect is the AP1 site within the …

Glucocorticoid hormones counteract inflammation and phorbol ester tumor promotion and
drastically decrease the expression of several extracellular proteases, including …