Lactate dehydrogenase (LDH) is one of the crucial enzymes in aerobic glycolysis, catalyzing
the last step of glycolysis, ie. the conversion of pyruvate to lactate. Most cancer cells are …

As a result of metabolic reprogramming, cancer cells display high rates of glycolysis,
causing an excess production of lactate along with an increase in extracellular acidity …

Despite great advances in the development of modern anticancer drugs, it is still challenging
to find safer and more effective ones due to a new spectrum of diseases and emerging drug …

Resistance to anticancer therapeutics occurs in virtually every type of cancer and becomes a
major difficulty in cancer treatment. Although 5-fluorouracil (5FU) is the first-line choice of …

Lactate dehydrogenase (LDH) is a crucial enzyme involved in energy metabolism and
present in various cells throughout the body. Its diverse physiological functions encompass …

Cancer cells reprogram their metabolism to become" glycolysis-dominant," which enables
them to meet their energy and macromolecule needs and enhancing their rate of survival …

A new series of thiazole central scaffold-based small molecules of h LDHA inhibitors were
designed using an in silico approach. Molecular docking analysis of designed molecules …

The inhibition of the hLDHA (human lactate dehydrogenase A) enzyme has been
demonstrated to be of great importance in the treatment of cancer and other diseases, such …

Chemical examination of a marine sponge-associated Penicillium copticola fungus resulted
in the isolation of ten undescribed eremophilanes, namely copteremophilanes A–J (1–10) …

Drug design and drug discovery is a passionate, prolonged, and inter-disciplinary multistep
process. The traditional drug discovery process is costly and time-consuming which …