Virus-like particles: preparation, immunogenicity and their roles as nanovaccines and drug nanocarriers

S Nooraei, H Bahrulolum, ZS Hoseini… - Journal of …, 2021 - Springer
Virus-like particles (VLPs) are virus-derived structures made up of one or more different
molecules with the ability to self-assemble, mimicking the form and size of a virus particle but …

Multifunctional biomolecule nanostructures for cancer therapy

J Wang, Y Li, G Nie - Nature Reviews Materials, 2021 - nature.com
Biomolecule-based nanostructures are inherently multifunctional and harbour diverse
biological activities, which can be explored for cancer nanomedicine. The supramolecular …

Interaction between virus-like particles (VLPs) and pattern recognition receptors (PRRs) from dendritic cells (DCs): toward better engineering of VLPs

J Zepeda-Cervantes, JO Ramírez-Jarquín… - Frontiers in …, 2020 - frontiersin.org
Virus-like particles (VLPs) have been shown to be strong activators of dendritic cells (DCs).
DCs are the most potent antigen presenting cells (APCs) and their activation prompts the …

Nanomedicine for increasing the oral bioavailability of cancer treatments

A Parodi, P Buzaeva, D Nigovora, A Baldin… - Journal of …, 2021 - Springer
Oral administration is an appealing route of delivering cancer treatments. However, the
gastrointestinal tract is characterized by specific and efficient physical, chemical, and …

Review of the role of nanotechnology in overcoming the challenges faced in oral cancer diagnosis and treatment

VR Umapathy, PM Natarajan, B Swamikannu - Molecules, 2023 - mdpi.com
Throughout the world, oral cancer is a common and aggressive malignancy with a high risk
of morbidity, mortality, and recurrence. The importance of early detection in cancer …

Towards the future exploration of mucosal mRNA vaccines against emerging viral diseases; lessons from existing next-generation mucosal vaccine strategies

SA Hameed, S Paul, GKY Dellosa, D Jaraquemada… - npj Vaccines, 2022 - nature.com
The mRNA vaccine platform has offered the greatest potential in fighting the COVID-19
pandemic owing to rapid development, effectiveness, and scalability to meet the global …

Oral vaccines: a better future of immunization

KWY Kwong, Y **n, NCY Lai, JCC Sung, KC Wu… - Vaccines, 2023 - mdpi.com
Oral vaccines are gaining more attention due to their ease of administration, lower
invasiveness, generally greater safety, and lower cost than injectable vaccines. This review …

[HTML][HTML] Translational challenges and prospective solutions in the implementation of biomimetic delivery systems

Z Wang, X Wang, W Xu, Y Li, R Lai, X Qiu, X Chen… - Pharmaceutics, 2023 - mdpi.com
Biomimetic delivery systems (BDSs), inspired by the intricate designs of biological systems,
have emerged as a groundbreaking paradigm in nanomedicine, offering unparalleled …

Current trends of targeted drug delivery for oral cancer therapy

M Zhang, J Liang, Y Yang, H Liang, H Jia… - … in bioengineering and …, 2020 - frontiersin.org
Oral cancer is an aggressive tumor that invades the local tissue and can cause metastasis
and high mortality. Conventional treatment strategies, eg, surgery, chemotherapy, and …

Engineering a nanoscale Al‐MOF‐armored antigen carried by a “trojan horse”‐like platform for oral vaccination to induce potent and long‐lasting immunity

YB Miao, WY Pan, KH Chen, HJ Wei… - Advanced Functional …, 2019 - Wiley Online Library
Vaccination via the oral administration of an antigen faces many challenges, including
gastrointestinal (GI) proteolysis and mucosal barriers. To limit GI proteolysis, a …