Immune rejection is an important obstacle to the use of allogeneic 'off-the-shelf'cells for
transplantation into immunocompetent patients. Genetic modification has emerged as a …

Personalized medicine aims to provide tailored medical treatment that considers the clinical,
genetic, and environmental characteristics of patients. iPSCs have attracted considerable …

Human induced pluripotent stem cell (iPSC) lines are a powerful tool for studying
development and disease, but the considerable phenotypic variation between lines makes it …

We developed a heart-on-a-chip platform that integrates highly flexible, vertical, 3D
micropillar electrodes for electrophysiological recording and elastic microwires for the …

Cardiovascular disease is a significant cause of death in humans. Various models are
necessary for the study of cardiovascular diseases, but once cellular and animal models …

Cardiomyopathy (CMP) is a heritable disorder. Over 50% of cases are gene-elusive on
clinical gene panel testing. The contribution of variants in non-coding DNA elements that …

Fluorogenic substrates are emerging tools that enable studying enzymatic processes within
their native cellular environments. However, fluorogenic substrates that function within live …

Loss of activity of the lysosomal glycosidase β-glucocerebrosidase (GCase) causes the
lysosomal storage disease Gaucher disease (GD) and has emerged as the greatest genetic …

Background Despite known clinical risk factors, predicting anthracycline cardiotoxicity
remains challenging. Objectives This study sought to develop a clinical and genetic risk …

Pathogenic variants in MYH7 and MYBPC3 account for the majority of hypertrophic
cardiomyopathy (HCM). Targeted drugs like myosin ATPase inhibitors have not been …