Motor neuron disease (MND) comprises a group of fatal neurodegenerative diseases with
no effective cure. As progressive motor neuron cell death is one of pathological …

The Erythropoietin-producing human hepatocellular carcinoma (Eph) receptors constitute
the largest family of receptor tyrosine kinases and interact with a group of ligands called …

Damage to the cerebrovascular network is a major contributor to dysfunction in patients
suffering from traumatic brain injury (TBI). Vessels are composed of lumen-forming …

Amyotrophic lateral sclerosis (ALS) is an untreatable, progressive, neurodegenerative
disease specifically affecting motor neurons. Recently, the tyrosine kinase receptor EphA4 …

EphA4, an Ephrins tyrosine kinase receptor, behaves as a dependence receptor (DR) by
triggering cell apoptosis in the absence of its ligand Ephrin-B3. DRs act as conditional tumor …

We demonstrate that EphB3 receptors mediate oligodendrocyte (OL) cell death in the
injured spinal cord through dependence receptor mechanism. OLs in the adult spinal cord …

Traumatic brain injury (TBI) elicits identifiable changes within the adult subventricular zone
(SVZ). Previously, we demonstrated that EphB3/ephrinB3 interaction inhibits neural …

Amyotrophic lateral sclerosis (ALS) is characterized by the degeneration of motor neurons,
leading to progressive muscle atrophy and fatal paralysis. Mutations in more than 20 genes …

Abstract Information about the molecular mechanisms leading to the activation of the
osteoclast is relatively limited. While there is compelling evidence that the signaling …

Clinical trials examining neuroprotective strategies after brain injury, including those
targeting cell death mechanisms, have been underwhelming. This may be in part due to an …