Endoplasmic reticulum stress and autophagy
Z Qi, L Chen - Autophagy: Biology and diseases: Basic science, 2019 - Springer
In 1945, KR Porter et al. observed mouse embryonic fibroblasts (MEFs) and found that the
cytoplasmic part of the cell had an unreported reticular structure, so it was named …
cytoplasmic part of the cell had an unreported reticular structure, so it was named …
Ceramide-orchestrated signalling in cancer cells
One crucial barrier to progress in the treatment of cancer has been the inability to control the
balance between cell proliferation and apoptosis: enter ceramide. Discoveries over the past …
balance between cell proliferation and apoptosis: enter ceramide. Discoveries over the past …
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …
Since then, this topic has received increasing attention, and many scientists have entered …
Autophagy: process and function
Autophagy is an intracellular degradation system that delivers cytoplasmic constituents to
the lysosome. Despite its simplicity, recent progress has demonstrated that autophagy plays …
the lysosome. Despite its simplicity, recent progress has demonstrated that autophagy plays …
Self-eating and self-killing: crosstalk between autophagy and apoptosis
MC Maiuri, E Zalckvar, A Kimchi… - Nature reviews Molecular …, 2007 - nature.com
The functional relationship between apoptosis ('self-killing') and autophagy ('self-eating') is
complex in the sense that, under certain circumstances, autophagy constitutes a stress …
complex in the sense that, under certain circumstances, autophagy constitutes a stress …
Pathogenic lysosomal depletion in Parkinson's disease
Mounting evidence suggests a role for autophagy dysregulation in Parkinson's disease
(PD). The bulk degradation of cytoplasmic proteins (including α-synuclein) and organelles …
(PD). The bulk degradation of cytoplasmic proteins (including α-synuclein) and organelles …
The regulation of autophagy by calcium signals: Do we have a consensus?
Abstract Macroautophagy (hereafter called 'autophagy') is a cellular process for degrading
and recycling cellular constituents, and for maintenance of cell function. Autophagy initiates …
and recycling cellular constituents, and for maintenance of cell function. Autophagy initiates …
Fighting neurodegeneration with rapamycin: mechanistic insights
A growing number of studies point to rapamycin as a pharmacological compound that is
able to provide neuroprotection in several experimental models of neurodegenerative …
able to provide neuroprotection in several experimental models of neurodegenerative …
Autophagy failure in A lzheimer's disease and the role of defective lysosomal acidification
Autophagy is a lysosomal degradative process which recycles cellular waste and eliminates
potentially toxic damaged organelles and protein aggregates. The important cytoprotective …
potentially toxic damaged organelles and protein aggregates. The important cytoprotective …
Connecting endoplasmic reticulum stress to autophagy by unfolded protein response and calcium
Eukaryotic cells respond to the accumulation of unfolded proteins in the endoplasmic
reticulum (ER) either by unfolded protein response that leads to an increase in the capacity …
reticulum (ER) either by unfolded protein response that leads to an increase in the capacity …