The evolving concepts of KS-WNK1 effect on NCC activity
The field of the with-no-lysine kinases (WNKs) regulation of the thiazide-sensitive NaCl
cotransporter (NCC) began at the start of the century with the discovery that mutations in two …
cotransporter (NCC) began at the start of the century with the discovery that mutations in two …
[PDF][PDF] KS-WNK1 amplifies kidney tubule responsiveness to potassium via WNK body condensates
CR Boyd-Shiwarski, RT Beacham, JA Lashway… - Biorxiv, 2021 - scholar.archive.org
The distal convoluted tubule (DCT) NaCl cotransporter NCC is activated by phosphorylation,
a process that is potassium-regulated and dependent on With-No-Lysine (WNK) kinases …
a process that is potassium-regulated and dependent on With-No-Lysine (WNK) kinases …
Disease-linked mutations dysregulate neuronal condensate physical properties, composition, and RNA translation
L Ahangama Liyanage, F McCready, S Chung… - bioRxiv, 2024 - biorxiv.org
Local RNA translation is essential for development. In neurons, deficient local translation
linked with mutations in scaffold proteins results in dysregulated dendrite and dendritic spine …
linked with mutations in scaffold proteins results in dysregulated dendrite and dendritic spine …
Familial Hyperkalemic Hypertension
RJ Cornelius, Y Maeoka, U Shinde… - Comprehensive …, 2011 - Wiley Online Library
Abstract The rare disease Familial Hyperkalemic Hypertension (FHHt) is caused by
mutations in the genes encoding Cullin 3 (CUL3), Kelch‐Like 3 (KLHL3), and two members …
mutations in the genes encoding Cullin 3 (CUL3), Kelch‐Like 3 (KLHL3), and two members …