Covering: up to June 2020 Ribosomally-synthesized and post-translationally modified
peptides (RiPPs) are a large group of natural products. A community-driven review in 2013 …

Develo** greener synthesis processes is an inescapable necessity to transform the
industrial landscape, mainly in the pharmaceutical sector, into a long-term, sustainable …

Site-specific protein modification is a widely-used biochemical tool. However, there are
many challenges associated with the development of protein modification techniques, in …

Natural extracellular vesicles (EVs) are ideal drug carriers due to their remarkable
biocompatibility. Their delivery specificity can be achieved by the conjugation of targeting …

This Review explores the class of plant-derived macrocyclic peptides called cyclotides. We
include an account of their discovery, characterization, and distribution in the plant kingdom …

Protein semisynthesis—defined herein as the assembly of a protein from a combination of
synthetic and recombinant fragments—is a burgeoning field of chemical biology that has …

Protein ligases of defined substrate specificity are versatile tools for protein engineering.
Upon completion of the reaction, the products of currently reported protein ligases contain …

The cyclisation of polypeptides can play a crucial role in exerting biological functions,
maintaining stability under harsh conditions and conferring proteolytic resistance, as …

Asparaginyl endopeptidases (AEPs) catalyze the key backbone cyclization step during the
biosynthesis of plant-derived cyclic peptides. Here, we report the identification of two AEPs …

Chemoenzymatic protein and peptide modification is a powerful means of generating
defined, homogeneous conjugates for a range of applications. However, the use of …