The roles of cyclins and their catalytic partners, the cyclin-dependent kinases (CDKs), as
core components of the machinery that drives cell cycle progression are well established …

Mitochondria are remarkably dynamic organelles that migrate, divide and fuse. Cycles of
mitochondrial fission and fusion ensure metabolite and mitochondrial DNA mixing and …

Cyclin dependent kinases (CDKs) are serine/threonine kinases that are proposed as
promising candidate targets for cancer treatment. These proteins complexed with cyclins …

Cyclin-dependent kinases (CDKs) are involved in many crucial processes, such as cell cycle
and transcription, as well as communication, metabolism, and apoptosis. The kinases are …

Traumatic brain injury (TBI) causes secondary biochemical changes that contribute to
subsequent tissue damage and associated neuronal cell death. Neuroprotective treatments …

Nonstandard abbreviations used: reactive oxygen species (ROS); Alzheimer disease (AD);
superoxide (O2•–); hydrogen peroxide (H2O2); superoxide dismutase (SOD); β-amyloid …

Harlequin (Hq) mutant mice have progressive degeneration of terminally differentiated
cerebellar and retinal neurons. We have identified the Hq mutation as a proviral insertion in …

Background—Neuroprotective drugs for acute stroke have appeared to work in animals,
only to fail when tested in humans. With the failure of so many clinical trials, the future of …

Neurons are usually regarded as postmitotic cells that undergo apoptosis in response to cell
cycle reactivation. Nevertheless, recent evidence indicates the existence of a defined …

Cyclin-dependent kinases (CDKs) regulate the cell division cycle, apoptosis, transcription
and differentiation in addition to functions in the nervous system. Deregulation of CDKs in …