The role of neurod genes in brain development, function, and disease
S Tutukova, V Tarabykin… - Frontiers in Molecular …, 2021 - frontiersin.org
Transcriptional regulation is essential for the correct functioning of cells during development
and in postnatal life. The basic Helix-loop-Helix (bHLH) superfamily of transcription factors is …
and in postnatal life. The basic Helix-loop-Helix (bHLH) superfamily of transcription factors is …
GAP-43 and BASP1 in axon regeneration: implications for the treatment of neurodegenerative diseases
D Chung, A Shum, G Caraveo - Frontiers in cell and developmental …, 2020 - frontiersin.org
Growth-associated protein-43 (GAP-43) and brain acid-soluble protein 1 (BASP1) regulate
actin dynamics and presynaptic vesicle cycling at axon terminals, thereby facilitating axonal …
actin dynamics and presynaptic vesicle cycling at axon terminals, thereby facilitating axonal …
[HTML][HTML] Human prefrontal cortex gene regulatory dynamics from gestation to adulthood at single-cell resolution
Human brain development is underpinned by cellular and molecular reconfigurations
continuing into the third decade of life. To reveal cell dynamics orchestrating neural …
continuing into the third decade of life. To reveal cell dynamics orchestrating neural …
Direct neuronal reprogramming: Fast forward from new concepts toward therapeutic approaches
R Bocchi, G Masserdotti, M Götz - Neuron, 2022 - cell.com
Differentiated cells have long been considered fixed in their identity. However, about 20
years ago, the first direct conversion of glial cells into neurons in vitro opened the field of" …
years ago, the first direct conversion of glial cells into neurons in vitro opened the field of" …
The IbPYL8–IbbHLH66–IbbHLH118 complex mediates the abscisic acid‐dependent drought response in sweet potato
L Xue, Z Wei, H Zhai, S **ng, Y Wang, S He… - New …, 2022 - Wiley Online Library
Drought limits crop development and yields. bHLH (basic helix–loop–helix) transcription
factors play critical roles in regulating the drought response in many plants, but their roles in …
factors play critical roles in regulating the drought response in many plants, but their roles in …
DNA-guided transcription factor cooperativity shapes face and limb mesenchyme
Transcription factors (TFs) can define distinct cellular identities despite nearly identical DNA-
binding specificities. One mechanism for achieving regulatory specificity is DNA-guided TF …
binding specificities. One mechanism for achieving regulatory specificity is DNA-guided TF …
Life cycle progression and sexual development of the apicomplexan parasite Cryptosporidium parvum
The apicomplexan parasite Cryptosporidium is a leading global cause of severe diarrhoeal
disease and an important contributor to early childhood mortality. Currently, there are no …
disease and an important contributor to early childhood mortality. Currently, there are no …
Single-cell transcriptomics revealed subtype-specific tumor immune microenvironments in human glioblastomas
Human glioblastoma (GBM), the most aggressive brain tumor, comprises six major subtypes
of malignant cells, giving rise to both inter-patient and intra-tumor heterogeneity. The …
of malignant cells, giving rise to both inter-patient and intra-tumor heterogeneity. The …
BORIS promotes chromatin regulatory interactions in treatment-resistant cancer cells
The CCCTC-binding factor (CTCF), which anchors DNA loops that organize the genome into
structural domains, has a central role in gene control by facilitating or constraining …
structural domains, has a central role in gene control by facilitating or constraining …
Mechanisms of binding specificity among bHLH transcription factors
The transcriptome of every cell is orchestrated by the complex network of interaction
between transcription factors (TFs) and their binding sites on DNA. Disruption of this network …
between transcription factors (TFs) and their binding sites on DNA. Disruption of this network …