The unfolded protein response (UPR) is a highly conserved pathway that allows the cell to
manage endoplasmic reticulum (ER) stress that is imposed by the secretory demands …

Tumor cells are often exposed to intrinsic and external factors that alter protein homeostasis,
thus producing endoplasmic reticulum (ER) stress. To cope with this, cells evoke an …

In BCR-ABL1 lymphoblastic leukemia, treatment heterogeneity to tyrosine kinase inhibitors
(TKIs), especially in the absence of kinase domain mutations in BCR-ABL1, is poorly …

Simple Summary The Inhibitor of Apoptosis (IAP) family of proteins has emerged as a
potential pharmacological target in cancer. Abnormal expression of IAPs can lead to …

Endoplasmic reticulum (ER) stress responses through the IRE-1/XBP-1 pathway are
required for the function of STING (TMEM173), an ER-resident transmembrane protein …

Stress induced by the accumulation of unfolded proteins in the endoplasmic reticulum (ER)
is observed in many human diseases, including cancers. Cellular adaptation to ER stress is …

Inositol-requiring enzyme type 1 (IRE1) is a serine/threonine kinase acting as one of three
branches of the Unfolded Protein Response (UPR) signaling pathway, which is activated …

The tumor microenvironment (TME) represents a dynamic network of cancer cells, stromal
cells, immune mediators, and extracellular matrix components, crucial for cancer …

An imbalance in the correct protein folding milieu of the endoplasmic reticulum (ER) can
cause ER stress, which leads to the activation of the unfolded protein response (UPR). The …

X-box binding protein 1 (XBP1) is a unique basic-region leucine zipper (bZIP) transcription
factor whose dynamic form is controlled by an alternative splicing response upon …