More than fifty years after the 3Rs definition and despite the continuous implementation of
regulatory measures, animals continue to be widely used in basic research. Their use …

Drug development for Alzheimer's disease, the leading cause of dementia, has been a long-
standing challenge. Saponins, which are steroid or triterpenoid glycosides with various …

Jujuboside A (JuA) is a triterpenoid saponins isolated from the seed of jujube (semen Ziziphi
spinosae) with anti-oxidant, anti-inflammation and anti-apoptosis properties. The present …

Neurological disorders generally have the characteristics of occult onset and progressive
development, which can do some serious damage to the human body in the aging process …

Fisetin has numerous therapeutic properties, such as anti-inflammatory, antioxidative, and
anticancer effects. However, the mechanism by which fisetin inhibits NLRP3 inflammasome …

Sleep is crucial for preserving both physical and mental health, including skin health.
Presently, there is a burgeoning interest in the use of herbal and natural ingredients to …

Alzheimer's disease (AD) is the most common neurodegenerative disorder worldwide.
Mitochondrial dysfunction is thought to be an early event in the onset and progression of AD; …

In this review article, we aimed to discuss the role of sleep deprivation (SD) in learning and
memory processing in basic and clinical studies. There are numerous studies investigating …

Transgenic mouse models serve a better understanding of Alzheimer's disease (AD)
pathogenesis and its consequences on neuronal function. Well-known and broadly used AD …

6-hydroxydopamine (6-OHDA) is used to induce oxidative damage in neuronal cells, which
can serve as an experimental model of Parkinson's disease (PD). Jujuboside A and B confer …