Mesenchymal stem cell-derived extracellular vesicles for immunomodulation and regeneration: a next generation therapeutic tool?

M Kou, L Huang, J Yang, Z Chiang, S Chen, J Liu… - Cell Death & …, 2022 - nature.com
Mesenchymal stem cells (MSCs) can be widely isolated from various tissues including bone
marrow, umbilical cord, and adipose tissue, with the potential for self-renewal and …

Challenges and advances in clinical applications of mesenchymal stromal cells

T Zhou, Z Yuan, J Weng, D Pei, X Du, C He… - Journal of hematology & …, 2021 - Springer
Mesenchymal stromal cells (MSCs), also known as mesenchymal stem cells, have been
intensely investigated for clinical applications within the last decades. However, the majority …

Reciprocal regulation of mesenchymal stem cells and immune responses

Y Wang, J Fang, B Liu, C Shao, Y Shi - Cell stem cell, 2022 - cell.com
Mesenchymal stem/stromal cells (MSCs) exist in almost all tissues and participate in tissue
regeneration and homeostasis. In-vitro-expanded MSCs are employed as therapeutics for …

[HTML][HTML] Mesenchymal stromal cells: putative microenvironmental modulators become cell therapy

M Krampera, K Le Blanc - Cell stem cell, 2021 - cell.com
An exceptional safety profile has been shown in a large number of cell therapy clinical trials
that use mesenchymal stromal cells (MSCs). However, reliable potency assays are still …

Current challenges and future directions for engineering extracellular vesicles for heart, lung, blood and sleep diseases

G Li, T Chen, J Dahlman… - Journal of …, 2023 - Wiley Online Library
Extracellular vesicles (EVs) carry diverse bioactive components including nucleic acids,
proteins, lipids and metabolites that play versatile roles in intercellular and interorgan …

Failure of cartilage regeneration: emerging hypotheses and related therapeutic strategies

S Muthu, JV Korpershoek, EJ Novais… - Nature Reviews …, 2023 - nature.com
Osteoarthritis (OA) is a disabling condition that affects billions of people worldwide and
places a considerable burden on patients and on society owing to its prevalence and …

[HTML][HTML] Mesenchymal stem cell-derived extracellular vesicles ameliorate Alzheimer's disease-like phenotypes in a preclinical mouse model

AS Cone, X Yuan, L Sun, LC Duke, MP Vreones… - Theranostics, 2021 - ncbi.nlm.nih.gov
Alzheimer's disease (AD) is an irreversible neurodegenerative disorder that affects more
than 44 million people worldwide. Despite the high disease burden, there is no effective …

Immunomodulation—a general review of the current state-of-the-art and new therapeutic strategies for targeting the immune system

M Strzelec, J Detka, P Mieszczak… - Frontiers in …, 2023 - frontiersin.org
In recent years, there has been a tremendous development of biotechnological,
pharmacological, and medical techniques which can be implemented in the functional …

Improved MSC minimal criteria to maximize patient safety: a call to embrace tissue factor and hemocompatibility assessment of MSC products

G Moll, JA Ankrum, SD Olson… - Stem cells translational …, 2022 - academic.oup.com
The number of mesenchymal stromal/stem cell (MSC) therapeutics and types of clinical
applications have greatly diversified during the past decade, including rapid growth of poorly …

Msx1+ stem cells recruited by bioactive tissue engineering graft for bone regeneration

X Zhang, W Jiang, C **e, X Wu, Q Ren, F Wang… - Nature …, 2022 - nature.com
Critical-sized bone defects often lead to non-union and full-thickness defects of the
calvarium specifically still present reconstructive challenges. In this study, we show that …