Regulation of gene expression is central to many biological processes. Although
reconstruction of regulatory circuits from genomic data alone is therefore desirable, this …

Huntington disease (HD) is a neurodegenerative disorder that predominantly affects
neurons of the forebrain. We have applied the Illumina massively parallel sequencing to …

The unicellular ancestor of animals had a complex repertoire of genes linked to multicellular
processes. This suggests that changes in the regulatory genome, rather than in gene …

High-throughput sequencing technologies enable direct approaches to catalog and analyze
snapshots of the total small RNA content of living cells. Characterization of high-throughput …

The laboratory rat is one of the most extensively studied model organisms. Inbred laboratory
rat strains originated from limited Rattus norvegicus founder populations, and the inherited …

Wings have provided an evolutionary advantage to insects and have allowed them to
diversify. Here, we have identified in Drosophila a highly robust regulatory mechanism that …

The velvet factor of the homothallic fungus Aspergillus nidulans promotes sexual fruiting
body formation. The encoding veA gene is conserved among fungi, including the …

T-Coffee (Tree-based consistency objective function for alignment evaluation) is a versatile
multiple sequence alignment (MSA) method suitable for aligning most types of biological …

The interplay of active and repressive histone modifications is assumed to have a key role in
the regulation of gene expression. In contrast to this generally accepted view, we show that …

The cyclin-cdk (cyclin-dependent kinase) inhibitor p27 Kip1 (p27) has a crucial negative role
on cell cycle progression. In addition to its classical role as a cyclin-cdk inhibitor, it also …