In diarthrodial joints, the articular cartilage, calcified cartilage, and subchondral cortical and
trabecular bone form a biocomposite—referred to as the osteochondral unit—that is …

Abstract TGF-β 1–3 are unique multi-functional growth factors that are only expressed in
mammals, and mainly secreted and stored as a latent complex in the extracellular matrix …

The classical view of the pathogenesis of osteoarthritis (OA) is that subchondral sclerosis is
associated with, and perhaps causes, age-related joint degeneration. Recent observations …

OA is a degenerative joint disease characterized by articular cartilage degradation,
osteophyte formation, synovitis, and subchondral bone sclerosis. One of OAs main risk …

Osteoarthritis (OA) is a degenerative joint disease characterized by joint pain and a
progressive loss of articular cartilage. Studies to elucidate the pathophysiology of OA have …

Background Histopathology has initially been and is still used to diagnose infectious,
degenerative or neoplastic diseases in humans or animals. In addition to qualitative …

A major symptom of patients with osteoarthritis (OA) is pain that is triggered by peripheral as
well as central changes within the pain pathways. The current treatments for OA pain such …

OBJECTIVE: Osteoarthritis (OA) is a chronic and slowly progressive disease for which
biomarkers may be able to provide a more rapid indication of therapeutic responses to …

Knee osteoarthritis remains a tremendous public health concern, both in terms of health‐
related quality of life and financial burden of disease. Translational research is a critical step …

Osteoarthritis (OA) is the most common form of arthritic disease, and a major cause of
disability and impaired quality of life in the elderly. OA is a complex disease of the entire …