Single cells in genetically homogeneous microbial cultures exhibit marked phenotypic
individuality, a biological phenomenon that is considered to bolster the fitness of …

The persistence of the human malaria parasite Plasmodium falciparum during blood stage
proliferation in its host depends on the successive expression of variant molecules at the …

Transmission represents a population bottleneck in the Plasmodium life cycle and a key
intervention target of ongoing efforts to eradicate malaria. Sexual differentiation is essential …

Malaria is caused by Plasmodium parasites that proliferate in the bloodstream. During each
replication cycle, some parasites differentiate into gametocytes, the only forms able to infect …

Clonally variant expression of surface antigens allows the malaria parasite Plasmodium
falciparum to evade immune recognition during blood stage infection and secure malaria …

Male and female gametocytes are the components of the malaria parasite life cycle which
are taken up from an infected host bloodstream by mosquitoes and thus mediate disease …

Clonally variant gene families underlie phenotypic plasticity in Plasmodium falciparum, a
process indispensable for survival of the pathogen in its human host. Differential …

The asexual forms of the malaria parasite Plasmodium falciparum are adapted for chronic
persistence in human red blood cells, continuously evading host immunity using …

The molecular mechanisms underlying transcriptional regulation in apicomplexan parasites
remain poorly understood. Recently, the Apicomplexan AP2 (ApiAP2) family of DNA binding …

Early data emerging from the first phase 3 trial of a malaria vaccine are raising hopes that a
licensed vaccine will soon be available for use in endemic countries, but given the relatively …