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Interferons and multiple sclerosis: Lessons from 25 years of clinical and real-world experience with intramuscular interferon beta-1a (Avonex)
Abstract Recombinant interferon (IFN) β-1b was approved by the US Food and Drug
Administration as the first disease-modifying therapy (DMT) for multiple sclerosis (MS) in …
Administration as the first disease-modifying therapy (DMT) for multiple sclerosis (MS) in …
[HTML][HTML] Innate viral sensor MDA5 and coxsackievirus interplay in type 1 diabetes development
Type 1 diabetes (T1D) is a polygenic autoimmune disease characterized by immune-
mediated destruction of insulin-producing β-cells. The concordance rate for T1D in …
mediated destruction of insulin-producing β-cells. The concordance rate for T1D in …
Alendronate promotes osteoblast differentiation and bone formation in ovariectomy-induced osteoporosis through interferon-β/signal transducer and activator of …
X Ma, Z Xu, S Ding, G Yi… - Experimental and …, 2018 - spandidos-publications.com
Alendronate is commonly used for the treatment of postmenopausal osteoporosis; however,
the underlying pathological molecular mechanisms of its action remain unclear. In the …
the underlying pathological molecular mechanisms of its action remain unclear. In the …
Neuroinflammation—using big data to inform clinical practice
Neuroinflammation is emerging as a central process in many neurological conditions, either
as a causative factor or as a secondary response to nervous system insult. Understanding …
as a causative factor or as a secondary response to nervous system insult. Understanding …
Pharmacogenetics: a strategy for personalized medicine for autoimmune diseases
For many years, a considerable number of patients with autoimmune diseases (ADs) have
suffered from a lack of drug response and drug‐related toxicity. Despite the emergence of …
suffered from a lack of drug response and drug‐related toxicity. Despite the emergence of …
miR-744-5p contributes to ocular inflammation in patients with primary Sjogrens Syndrome
In primary Sjögren's syndrome (pSS) the exocrine glands become infiltrated with
lymphocytes instigating severe damage to the salivary and lacrimal glands causing dry eyes …
lymphocytes instigating severe damage to the salivary and lacrimal glands causing dry eyes …
Pharmacogenomics of multiple sclerosis: a systematic review
Background: Over the past two decades, various novel disease-modifying drugs for multiple
sclerosis (MS) have been approved. However, there is high variability in the patient …
sclerosis (MS) have been approved. However, there is high variability in the patient …
Recent developments in interferon-based therapies for multiple sclerosis
Introduction: Multiple sclerosis (MS) is a chronic and disabling immune-mediated disease of
the central nervous system. Beta-interferons are the first approved and still the most widely …
the central nervous system. Beta-interferons are the first approved and still the most widely …
Gamma-aminobutyric acid (GABA) receptors genes polymorphisms and risk for restless legs syndrome
FJ Jiménez-Jiménez, G Esguevillas… - The …, 2018 - nature.com
The possible role of gammaaminobutyric acid (GABA) in the pathophysiology of restless
legs syndrome (RLS) is suggested by the symptomatic improvement achieved with …
legs syndrome (RLS) is suggested by the symptomatic improvement achieved with …
Effect of genetic polymorphisms on therapeutic response in multiple sclerosis relapsing-remitting patients treated with interferon-beta
Abstract Treatment with interferon beta (IFNβ) is one of the first-line treatments for multiple
sclerosis. In clinical practice, however, many patients present suboptimal response to IFNβ …
sclerosis. In clinical practice, however, many patients present suboptimal response to IFNβ …