Hepatitis virus and hepatocellular carcinoma: recent advances

C Shen, X Jiang, M Li, Y Luo - Cancers, 2023 - mdpi.com
Simple Summary Hepatocellular carcinoma (HCC) is a global health challenge. Hepatitis
virus infection (including HBV, HCV and HDV) is one of the major risk factors for HCC …

[HTML][HTML] Chronic hepatitis E: Advancing research and patient care

Z Ma, RA de Man, N Kamar, Q Pan - Journal of Hepatology, 2022 - Elsevier
The hepatitis E virus (HEV) was initially thought to exclusively cause acute hepatitis.
However, the first diagnosis of chronic hepatitis E in transplant recipients in 2008 profoundly …

Recapitulating hepatitis E virus–host interactions and facilitating antiviral drug discovery in human liver–derived organoids

P Li, Y Li, Y Wang, J Liu, M Lavrijsen, Y Li, R Zhang… - Science …, 2022 - science.org
Hepatotropic viruses naturally have narrow host and tissue tropisms, challenging the
development of robust experimental models. The advent of organoid technology provides a …

Hepatitis E: An update on One Health and clinical medicine

TP Velavan, SR Pallerla, R Johne, D Todt… - Liver …, 2021 - Wiley Online Library
The hepatitis E virus (HEV) is one of the main causes of acute hepatitis and the de facto
global burden is underestimated. HEV‐related clinical complications are often undetected …

Cell entry and release of quasi-enveloped human hepatitis viruses

A Das, EE Rivera-Serrano, X Yin, CM Walker… - Nature Reviews …, 2023 - nature.com
Infectious hepatitis type A and type E are caused by phylogenetically distinct single-
stranded, positive-sense RNA viruses that were once considered to be non-enveloped …

Hepatitis E virus infection: circulation, molecular epidemiology, and impact on global health

SR Pallerla, D Harms, R Johne, D Todt, E Steinmann… - Pathogens, 2020 - mdpi.com
Infection with hepatitis E virus (HEV) represents the most common source of viral hepatitis
globally. Although infecting over 20 million people annually in endemic regions, with major …

Virus–host cell interplay during hepatitis E virus infection

MH Wißing, Y Brüggemann, E Steinmann, D Todt - Trends in microbiology, 2021 - cell.com
The molecular interplay between cellular host factors and viral proteins is a continuous
process throughout the viral life cycle determining virus host range and pathogenesis. The …

[HTML][HTML] Structural and molecular biology of hepatitis E virus

B Wang, XJ Meng - Computational and Structural Biotechnology Journal, 2021 - Elsevier
Hepatitis E virus (HEV) is one of the most common causes of acute viral hepatitis, mainly
transmitted by fecal-oral route but has also been linked to fulminant hepatic failure, chronic …

Hepatitis E virus: from innate sensing to adaptive immune responses

Y Brüggemann, M Klöhn, H Wedemeyer… - Nature Reviews …, 2024 - nature.com
Hepatitis E virus (HEV) infections are a major cause of acute viral hepatitis in humans
worldwide. In immunocompetent individuals, the majority of HEV infections remain …

An immunocompetent Mongolian gerbil model for hepatitis E virus genotype 1 infection

T Liu, Q He, X Yang, Y Li, D Yuan, Q Lu, T Tang… - Gastroenterology, 2024 - Elsevier
Background & Aims Hepatitis E virus (HEV), primarily genotype 1 (HEV-1), causes
approximately 20.1 million infections, 44,000 deaths, and 3000 stillbirths annually. Current …