The mucus clearance system is the dominant mechanical host defense system of the human
lung. Mucus is cleared from the lung by cilia and airflow, including both two-phase gas-liquid …

Pulmonary infections caused by the mould pathogen Aspergillus fumigatus are a major
cause of morbidity and mortality globally. Compromised lung defences arising from …

Muco-obstructive lung diseases are typically associated with high risks of COVID-19
severity; however, allergic asthma showed reduced susceptibility. To investigate viral …

Rhinoviruses (RVs), which are the most common cause of virally induced asthma
exacerbations, account for much of the burden of asthma in terms of morbidity, mortality, and …

Inhaled corticosteroids (ICS) have limited efficacy in reducing chronic obstructive pulmonary
disease (COPD) exacerbations and increase pneumonia risk, through unknown …

The respiratory tract surface is protected from inhaled pathogens by a secreted layer of
mucus rich in mucin glycoproteins. Abnormal mucus accumulation is a cardinal feature of …

The human body is colonized by a wide range of microorganisms. The field of viromics has
expanded since the first reports on the detection of viruses via metagenomic sequencing in …

Mucus pathology in cystic fibrosis (CF) has been known for as long as the disease has been
recognized and is sometimes called mucoviscidosis. The disease is marked by mucus …

Elevated levels of MUC5AC, one of the major gel-forming mucins in the lungs, are closely
associated with chronic obstructive lung diseases such as chronic bronchitis and asthma. It …

Viral-induced exacerbation of asthma remains a major cause of hospitalization and
mortality. New human-relevant models of the airways are urgently needed to understand …