The challenge of HIV-1 subtype diversity
HIV-1 has evolved multiple mechanisms to elude immune control. The view of virus as
classifiable into distinct subtypes needs to reflect the reality of the constant emergence of …
classifiable into distinct subtypes needs to reflect the reality of the constant emergence of …
HIV-1 envelope glycoprotein biosynthesis, trafficking, and incorporation
MA Checkley, BG Luttge, EO Freed - Journal of molecular biology, 2011 - Elsevier
The HIV-1 envelope (Env) glycoproteins play an essential role in the virus replication cycle
by mediating the fusion between viral and cellular membranes during the entry process. The …
by mediating the fusion between viral and cellular membranes during the entry process. The …
Learning the language of viral evolution and escape
The ability for viruses to mutate and evade the human immune system and cause infection,
called viral escape, remains an obstacle to antiviral and vaccine development …
called viral escape, remains an obstacle to antiviral and vaccine development …
A neutralizing antibody selected from plasma cells that binds to group 1 and group 2 influenza A hemagglutinins
D Corti, J Voss, SJ Gamblin, G Codoni, A Macagno… - Science, 2011 - science.org
The isolation of broadly neutralizing antibodies against influenza A viruses has been a long-
sought goal for therapeutic approaches and vaccine design. Using a single-cell culture …
sought goal for therapeutic approaches and vaccine design. Using a single-cell culture …
Phylogeny-aware gap placement prevents errors in sequence alignment and evolutionary analysis
Genetic sequence alignment is the basis of many evolutionary and comparative studies, and
errors in alignments lead to errors in the interpretation of evolutionary information in …
errors in alignments lead to errors in the interpretation of evolutionary information in …
[HTML][HTML] Human antibodies that neutralize HIV-1: identification, structures, and B cell ontogenies
PD Kwong, JR Mascola - Immunity, 2012 - cell.com
Antibodies that neutralize diverse strains of HIV-1 develop in∼ 20% of HIV-1-infected
individuals, and isolation and structural characterization of these antibodies are revealing …
individuals, and isolation and structural characterization of these antibodies are revealing …
Virus glycosylation: role in virulence and immune interactions
DJ Vigerust, VL Shepherd - Trends in microbiology, 2007 - cell.com
The study of N-linked glycosylation as it relates to virus biology has become an area of
intense interest in recent years due to its ability to impart various advantages to virus survival …
intense interest in recent years due to its ability to impart various advantages to virus survival …
Deciphering human immunodeficiency virus type 1 transmission and early envelope diversification by single-genome amplification and sequencing
JF Salazar-Gonzalez, E Bailes, KT Pham… - Journal of …, 2008 - Am Soc Microbiol
Accurate identification of the transmitted virus and sequences evolving from it could be
instrumental in elucidating the transmission of human immunodeficiency virus type 1 (HIV-1) …
instrumental in elucidating the transmission of human immunodeficiency virus type 1 (HIV-1) …
A broadly neutralizing antibody targets the dynamic HIV envelope trimer apex via a long, rigidified, and anionic β-hairpin structure
Broadly neutralizing antibodies (bnAbs) to HIV delineate vaccine targets and are
prophylactic and therapeutic agents. Some of the most potent bnAbs target a quaternary …
prophylactic and therapeutic agents. Some of the most potent bnAbs target a quaternary …
Research article (new england journal of medicine) severe anemia in malawian children
Background: Severe anemia is a major cause of sickness and death in African children, yet
the causes of anemia in this population have been inadequately studied. Methods: We …
the causes of anemia in this population have been inadequately studied. Methods: We …