Notable changes in lung cancer epidemiology and prevention have occurred over the past
decade owing to changes in smoking patterns, groundbreaking advances in our …

Although all cancers share common hallmarks, we have long realized that there is no silver-
bullet treatment for the disease. Many clinical oncologists specialize in a single cancer type …

Head and neck squamous cell carcinoma is the sixth most common cancer worldwide and
has high heterogeneity and unsatisfactory outcomes. To better characterize the tumor …

We present a proteogenomic study of 108 human papilloma virus (HPV)-negative head and
neck squamous cell carcinomas (HNSCCs). Proteomic analysis systematically catalogs …

Gene fusions represent an important class of somatic alterations in cancer. We
systematically investigated fusions in 9,624 tumors across 33 cancer types using multiple …

Here, as part of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, for
which whole-genome and—for a subset—whole-transcriptome sequencing data from 2,658 …

Summary The Cancer Genome Atlas (TCGA) has catalyzed systematic characterization of
diverse genomic alterations underlying human cancers. At this historic junction marking the …

Recent studies have revealed the mutational signatures underlying the somatic evolution of
cancer, and the prevalences of associated somatic genetic variants. Here we estimate the …

Hepatitis B virus (HBV), which was discovered in 1965, is a threat to global public health.
HBV infects human hepatocytes and leads to acute and chronic liver diseases, and there is …

Viral infection is an indisputable causal factor for nearly 17% of all human cancers.
However, the diversity and complexity of oncogenic mechanisms raises new questions as to …