The evolving metabolic landscape of chromatin biology and epigenetics

Z Dai, V Ramesh, JW Locasale - Nature Reviews Genetics, 2020 - nature.com
Molecular inputs to chromatin via cellular metabolism are modifiers of the epigenome. These
inputs—which include both nutrient availability as a result of diet and growth factor signalling …

Perspectives on skeletal muscle stem cells

F Relaix, M Bencze, MJ Borok, A Der Vartanian… - Nature …, 2021 - nature.com
Skeletal muscle has remarkable regeneration capabilities, mainly due to its resident muscle
stem cells (MuSCs). In this review, we introduce recently developed technologies and the …

Metabolic determination of cell fate through selective inheritance of mitochondria

J Döhla, E Kuuluvainen, N Gebert, A Amaral… - Nature cell …, 2022 - nature.com
Metabolic characteristics of adult stem cells are distinct from their differentiated progeny, and
cellular metabolism is emerging as a potential driver of cell fate conversions,,–. How these …

Role of autophagy in aging: The good, the bad, and the ugly

S Tabibzadeh - Aging Cell, 2023 - Wiley Online Library
Autophagy (self‐eating) is a conserved catabolic homeostatic process required for cellular
metabolic demands by removal of the damaged molecules and organelles and for …

Mitochondrial function—gatekeeper of intestinal epithelial cell homeostasis

E Rath, A Moschetta, D Haller - Nature reviews Gastroenterology & …, 2018 - nature.com
The intestinal epithelium is a multicellular interface in close proximity to a dense microbial
milieu that is completely renewed every 3–5 days. Pluripotent stem cells reside at the crypt …

Regulation of adult neurogenesis in mammalian brain

MV Niklison-Chirou, M Agostini, I Amelio… - International Journal of …, 2020 - mdpi.com
Adult neurogenesis is a multistage process by which neurons are generated and integrated
into existing neuronal circuits. In the adult brain, neurogenesis is mainly localized in two …

Nrf2: redox and metabolic regulator of stem cell state and function

X Dai, X Yan, KA Wintergerst, L Cai, BB Keller… - Trends in Molecular …, 2020 - cell.com
Nuclear factor erythroid 2-related factor 2 (Nrf2) is ubiquitously expressed in most eukaryotic
cells and functions to induce a broad range of cellular defenses against exogenous and …

Trehalose-6-phosphate signaling regulates lateral root formation in Arabidopsis thaliana

S Morales-Herrera, J Jourquin… - Proceedings of the …, 2023 - National Acad Sciences
Plant roots explore the soil for water and nutrients, thereby determining plant fitness and
agricultural yield, as well as determining ground substructure, water levels, and global …

Dietary approaches to cancer therapy

M Tajan, KH Vousden - Cancer cell, 2020 - cell.com
The concept that dietary changes could improve the response to cancer therapy is extremely
attractive to many patients, who are highly motivated to take control of at least some aspect …

Advances and challenges in cell biology for cultured meat

B Martins, A Bister, RGJ Dohmen… - Annual review of …, 2024 - annualreviews.org
Cultured meat is an emerging biotechnology that aims to produce meat from animal cell
culture, rather than from the raising and slaughtering of livestock, on environmental and …