DNA sequencing at 40: past, present and future
This review commemorates the 40th anniversary of DNA sequencing, a period in which we
have already witnessed multiple technological revolutions and a growth in scale from a few …
have already witnessed multiple technological revolutions and a growth in scale from a few …
The Human Gene Mutation Database: towards a comprehensive repository of inherited mutation data for medical research, genetic diagnosis and next-generation …
Abstract The Human Gene Mutation Database (HGMD®) constitutes a comprehensive
collection of published germline mutations in nuclear genes that underlie, or are closely …
collection of published germline mutations in nuclear genes that underlie, or are closely …
Evolution of the germline mutation rate across vertebrates
The germline mutation rate determines the pace of genome evolution and is an evolving
parameter itself. However, little is known about what determines its evolution, as most …
parameter itself. However, little is known about what determines its evolution, as most …
BlobToolKit–interactive quality assessment of genome assemblies
Reconstruction of target genomes from sequence data produced by instruments that are
agnostic as to the species-of-origin may be confounded by contaminant DNA. Whether …
agnostic as to the species-of-origin may be confounded by contaminant DNA. Whether …
[کتاب][B] tRNAscan-SE: searching for tRNA genes in genomic sequences
Transfer RNAs are the largest, most complex non-coding RNA family, universal to all living
organisms. tRNAscan-SE has been the de facto tool for predicting tRNA genes in whole …
organisms. tRNAscan-SE has been the de facto tool for predicting tRNA genes in whole …
tRNAscan-SE 2.0: improved detection and functional classification of transfer RNA genes
Abstract tRNAscan-SE has been widely used for transfer RNA (tRNA) gene prediction for
over twenty years, developed just as the first genomes were decoded. With the massive …
over twenty years, developed just as the first genomes were decoded. With the massive …
The Ensembl gene annotation system
The Ensembl gene annotation system has been used to annotate over 70 different
vertebrate species across a wide range of genome projects. Furthermore, it generates the …
vertebrate species across a wide range of genome projects. Furthermore, it generates the …
A SARS-CoV-2 targeted siRNA-nanoparticle therapy for COVID-19
Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infection in humans. Despite several emerging vaccines, there …
coronavirus 2 (SARS-CoV-2) infection in humans. Despite several emerging vaccines, there …
Rodent models in neuroscience research: is it a rat race?
Rodents (especially Mus musculus and Rattus norvegicus) have been the most widely used
models in biomedical research for many years. A notable shift has taken place over the last …
models in biomedical research for many years. A notable shift has taken place over the last …
The long noncoding RNA Malat1: Its physiological and pathophysiological functions
Recent studies suggest that in humans, DNA sequences responsible for protein coding
regions comprise only 2% of the total genome. The rest of the transcripts result in RNA …
regions comprise only 2% of the total genome. The rest of the transcripts result in RNA …