Summary Background Resistance of Plasmodium falciparum to sulfadoxine-pyrimethamine
threatens the antimalarial effectiveness of intermittent preventive treatment during …

Late-stage modification of drug molecules is a fast method to introduce diversity into the
already biologically active scaffold. A notable number of analogs of mefloquine, chloroquine …

As part of the global effort toward malaria eradication, phenotypic whole-cell screening
revealed the 2-aminopyridine class of small molecules as a good starting point to develop …

Deletions of the Plasmodium falciparum hrp2 and hrp3 genes can affect the performance of
HRP2-based malaria rapid diagnostic tests (RDTs). Such deletions have been reported from …

We present case histories of four patients treated with artemether-lumefantrine for falciparum
malaria in UK hospitals in 2015 to 2016. Each subsequently presented with recurrent …

Background Recent cases of clinical failure in malaria patients in the United Kingdom (UK)
treated with artemether-lumefantrine have implications for malaria chemotherapy worldwide …

Background The efficacy of artemisinin-based combination therapy (ACT) for Plasmodium
falciparum malaria may be threatened by parasites with reduced responsiveness to …

Background Many health facilities in malaria endemic countries are dependent on Rapid
diagnostic tests (RDTs) for diagnosis and some National Health Service (NHS) hospitals …

Introduction Malaria remains a devastating infectious disease with hundreds of thousands of
casualties each year. Antimalarial drug resistance has been a threat to malaria control and …

Antimalarial drug resistance and unavailability of effective vaccine warrant for newer drugs
and drug targets. Hence, anti-inflammatory activity of phyto-compound (oleuropein; OLP) …