Extracellular vesicles: biology and emerging therapeutic opportunities
S El Andaloussi, I Mäger, XO Breakefield… - Nature reviews Drug …, 2013 - nature.com
Within the past decade, extracellular vesicles have emerged as important mediators of
intercellular communication, being involved in the transmission of biological signals …
intercellular communication, being involved in the transmission of biological signals …
Mesenchymal stem cell secretome: toward cell-free therapeutic strategies in regenerative medicine
FJ Vizoso, N Eiro, S Cid, J Schneider… - International journal of …, 2017 - mdpi.com
Earlier research primarily attributed the effects of mesenchymal stem cell (MSC) therapies to
their capacity for local engrafting and differentiating into multiple tissue types. However …
their capacity for local engrafting and differentiating into multiple tissue types. However …
[HTML][HTML] Dosing extracellular vesicles
D Gupta, AM Zickler, S El Andaloussi - Advanced drug delivery reviews, 2021 - Elsevier
Extracellular vesicles (EVs) are natural nanoparticles containing biologically active
molecules. They are important mediators of intercellular communication and can be …
molecules. They are important mediators of intercellular communication and can be …
Extracellular vesicle in vivo biodistribution is determined by cell source, route of administration and targeting
OPB Wiklander, JZ Nordin, A O'Loughlin… - Journal of …, 2015 - Taylor & Francis
Extracellular vesicles (EVs) have emerged as important mediators of intercellular
communication in a diverse range of biological processes. For future therapeutic …
communication in a diverse range of biological processes. For future therapeutic …
Native and bioengineered extracellular vesicles for cardiovascular therapeutics
RC de Abreu, H Fernandes… - Nature reviews …, 2020 - nature.com
Extracellular vesicles (EVs) are a heterogeneous group of natural particles that are relevant
to the treatment of cardiovascular diseases. These endogenous vesicles have certain …
to the treatment of cardiovascular diseases. These endogenous vesicles have certain …
Advances in exosome-based drug delivery and tumor targeting: from tissue distribution to intracellular fate
J Shao, J Zaro, Y Shen - International journal of nanomedicine, 2020 - Taylor & Francis
Exosomes or small extracellular vesicles are considered a new generation of bioinspired-
nanoscale drug delivery system (DDS). Endogenous exosomes function as signalosomes …
nanoscale drug delivery system (DDS). Endogenous exosomes function as signalosomes …
Immunobiology of mesenchymal stem cells
Mesenchymal stem cells (MSCs) can be isolated from almost all tissues and effectively
expanded in vitro. Although their true in situ properties and biological functions remain to be …
expanded in vitro. Although their true in situ properties and biological functions remain to be …
The mesenchymal stem cell secretome: A new paradigm towards cell-free therapeutic mode in regenerative medicine
Abstract Mesenchymal Stem Cells (MSCs) have been shown to be a promising candidate for
cell-based therapy. The therapeutic potential of MSCs, towards tissue repair and wound …
cell-based therapy. The therapeutic potential of MSCs, towards tissue repair and wound …
Biomaterials functionalized with MSC secreted extracellular vesicles and soluble factors for tissue regeneration
The therapeutic benefits of mesenchymal stromal cell (MSC) transplantation are attributed to
their secreted factors, including extracellular vesicles (EVs) and soluble factors. The …
their secreted factors, including extracellular vesicles (EVs) and soluble factors. The …
[HTML][HTML] Ultrafiltration with size-exclusion liquid chromatography for high yield isolation of extracellular vesicles preserving intact biophysical and functional properties
Extracellular vesicles (EVs) are natural nanoparticles that mediate intercellular transfer of
RNA and proteins and are of great medical interest; serving as novel biomarkers and …
RNA and proteins and are of great medical interest; serving as novel biomarkers and …