The delivery of therapeutic oligonucleotides
RL Juliano - Nucleic acids research, 2016 - academic.oup.com
The oligonucleotide therapeutics field has seen remarkable progress over the last few years
with the approval of the first antisense drug and with promising developments in late stage …
with the approval of the first antisense drug and with promising developments in late stage …
Editorial focus: understanding off-target effects as the key to successful RNAi therapy
R Bartoszewski, AF Sikorski - Cellular & molecular biology letters, 2019 - Springer
With the first RNA interference (RNAi) drug (ONPATTRO (patisiran)) on the market, we
witness the RNAi therapy field reaching a critical turning point, when further improvements in …
witness the RNAi therapy field reaching a critical turning point, when further improvements in …
A review on cationic lipids with different linkers for gene delivery
D Zhi, Y Bai, J Yang, S Cui, Y Zhao, H Chen… - Advances in colloid and …, 2018 - Elsevier
Cationic lipids have become known as one of the most versatile tools for the delivery of
DNA, RNA and many other therapeutic molecules, and are especially attractive because …
DNA, RNA and many other therapeutic molecules, and are especially attractive because …
Lipid–Polymer Hybrid Nanoparticles with Both PD-L1 Knockdown and Mild Photothermal Effect for Tumor Photothermal Immunotherapy
D Chuan, R Fan, B Chen, Y Ren, M Mu… - … Applied Materials & …, 2023 - ACS Publications
In develo** countries, the incidence of colorectal cancer (CRC) is on the rise. The
combination of programmed cell death ligand-1 (PD-L1) siRNA (siPD-L1) and mild …
combination of programmed cell death ligand-1 (PD-L1) siRNA (siPD-L1) and mild …
Non-viral nanocarriers for intracellular delivery of microRNA therapeutics
Z Bai, J Wei, C Yu, X Han, X Qin, C Zhang… - Journal of Materials …, 2019 - pubs.rsc.org
MicroRNAs are small regulatory noncoding RNAs that regulate various biological processes
associated with neurological disorders, cardiovascular diseases, cancer and viral infection …
associated with neurological disorders, cardiovascular diseases, cancer and viral infection …
microRNAs as novel therapeutics in cancer
Simple Summary Over the last few years, we have witnessed incredible advancements in
anti-tumor drug development. microRNAs, a class of small non-coding RNAs dysregulated …
anti-tumor drug development. microRNAs, a class of small non-coding RNAs dysregulated …
Oligonucleotide probes for imaging and diagnosis of bacterial infections
L Moreira, NM Guimarães, RS Santos… - Critical Reviews in …, 2025 - Taylor & Francis
The rise of infectious diseases as a public health concern has necessitated the development
of rapid and precise diagnostic methods. Imaging techniques like nuclear and optical …
of rapid and precise diagnostic methods. Imaging techniques like nuclear and optical …
Functionalized liposomes as drug nanocarriers for active targeted cancer therapy: a systematic review
Cancer is a broad term used to describe a group of diseases that have more than 270 types.
Today, due to the suffering of patients from the side effects of existing methods in the …
Today, due to the suffering of patients from the side effects of existing methods in the …
Building blocks to design liposomal delivery systems
K Juszkiewicz, AF Sikorski, A Czogalla - International Journal of …, 2020 - mdpi.com
The flexibility of liposomal carriers does not just simply rely on their capability to encapsulate
various types of therapeutic substances, but also on the large array of components used for …
various types of therapeutic substances, but also on the large array of components used for …
Endocytosis in cellular uptake of drug delivery vectors: Molecular aspects in drug development
Z Kaźmierczak, K Szostak-Paluch, M Przybyło… - Bioorganic & Medicinal …, 2020 - Elsevier
Drug delivery vectors are widely applied to increase drug efficacy while reducing the side
effects and potential toxicity of a drug. They allow for patient-tailored therapy, dose titration …
effects and potential toxicity of a drug. They allow for patient-tailored therapy, dose titration …