Autophagy is a catabolic process for unnecessary or dysfunctional cytoplasmic contents by
lysosomal degradation pathways. Autophagy is implicated in various biological processes …

During tumorigenesis, cancer cells are exposed to a wide variety of intrinsic and extrinsic
stresses that challenge homeostasis and growth. Cancer cells display activation of distinct …

Immune evasion is a major obstacle for cancer treatment. Common mechanisms of evasion
include impaired antigen presentation caused by mutations or loss of heterozygosity of the …

Selective autophagy recycles damaged organelles and clears intracellular pathogens to
prevent their aberrant accumulation. How ULK1 kinase is targeted and activated during …

Autophagy and the ubiquitin–proteasome system (UPS) are the two major intracellular
quality control and recycling mechanisms that are responsible for cellular homeostasis in …

The ubiquitin–proteasome system (UPS) and autophagy are two distinct and interacting
proteolytic systems. They play critical roles in cell survival under normal conditions and …

Understanding the function of genes mutated in hereditary forms of Parkinson's disease
yields insight into disease etiology and reveals new pathways in cell biology. Although …

Selective autophagy of damaged mitochondria requires autophagy receptors optineurin
(OPTN), NDP52 (CALCOCO2), TAX1BP1, and p62 (SQSTM1) linking ubiquitinated cargo to …

Macroautophagic clearance of cytosolic materials entails the initiation, growth and closure of
autophagosomes. Cargo triggers the assembly of a web of cargo receptors and core …

Oral squamous cell carcinoma (OSCC) is the most common type of oral malignancy, and
metastasis accounts for the poor prognosis of OSCC. Autophagy is considered to facilitate …