Antibiotic discovery and resistance: the chase and the race

K Iskandar, J Murugaiyan, D Hammoudi Halat… - Antibiotics, 2022 - mdpi.com
The history of antimicrobial resistance (AMR) evolution and the diversity of the
environmental resistome indicate that AMR is an ancient natural phenomenon. Acquired …

Immunomodulatory biomaterials against bacterial infections: Progress, challenges, and future perspectives

S Zhang, H Yang, M Wang, D Mantovani, K Yang… - The Innovation, 2023 - cell.com
Bacterial infectious diseases are one of the leading causes of death worldwide. Even with
the use of multiple antibiotic treatment strategies, 4.95 million people died from drug …

Global antimicrobial resistance and use surveillance system (GLASS 2022): Investigating the relationship between antimicrobial resistance and antimicrobial …

S Ajulo, B Awosile - PLoS One, 2024 - journals.plos.org
For the first time since 2015, the World Health Organization's (WHO) global Antimicrobial
Resistance and Use Surveillance (GLASS) featured both global reports for antimicrobial …

Encouraging the development of new antibiotics: are financial incentives the right way forward? A systematic review and case study

IA Dutescu, SA Hillier - Infection and drug resistance, 2021 - Taylor & Francis
Antibiotic resistance is an urgent public health threat that has received substantial attention
from the world's leading health agencies and national governmental bodies alike. However …

A how-to guide for mode of action analysis of antimicrobial peptides

AB Schäfer, M Wenzel - Frontiers in cellular and infection microbiology, 2020 - frontiersin.org
Antimicrobial peptides (AMPs) are a promising alternative to classical antibiotics in the fight
against multi-resistant bacteria. They are produced by organisms from all domains of life and …

[HTML][HTML] Genomic characterization of lytic bacteriophages targeting genetically diverse Pseudomonas aeruginosa clinical isolates

HR Nordstrom, DR Evans, AG Finney, KJ Westbrook… - Iscience, 2022 - cell.com
Pseudomonas aeruginosa infections can be difficult to treat and new therapeutics are
needed. Bacteriophage therapy is a promising alternative to traditional antibiotics, but large …

(Inter) nationalising the antibiotic research and development pipeline

AC Singer, C Kirchhelle, AP Roberts - The Lancet Infectious …, 2020 - thelancet.com
Summary In this Personal View, we critically examine the wider context of international
efforts to stimulate commercial antibiotic research and development via public–private …

Economies of resistance

M Peterie, A Broom, K Kenny, J Broom… - Critical Public …, 2023 - Taylor & Francis
The social organisation of economic life plays a pivotal role in assembling many emerging
and enduring health problems. Yet throughout the recent history of global health challenges …

Global access to existing and future antimicrobials and diagnostics: antimicrobial subscription and pooled procurement

D Berman, SJ Chandy, O Cansdell… - The Lancet Global …, 2022 - thelancet.com
The COVID-19 pandemic has underlined the importance of an efficient and equitable supply
of and access to essential health products. These factors are equally pertinent to the …

Efficacy of a novel antimicrobial hydrogel for eradication of Staphylococcus epidermidis, Staphylococcus aureus and Cutibacterium acnes from preformed biofilm and treatment …

T Ronco, MF Aragao, S Svenningsen… - JAC-Antimicrobial …, 2021 - academic.oup.com
Background Bacterial biofilm formation is a complicating factor in the antimicrobial treatment
of bacterial infections. Objectives In this study, we assessed the impact of a novel hydrogel …