The fields of application of functional proteomics are not limited to the study of protein–
protein interactions; they also extend to those involving protein complexes that bind DNA or …

The Flavivirus genus comprises many viruses (including dengue, Zika, West Nile and yellow
fever viruses) which constitute important public health concerns worldwide. For several of …

Hepatitis C virus (HCV) is a major cause of chronic liver disease affecting around 130 million
people worldwide. While great progress has been made to define the principle steps of the …

RNAs play critical roles in diverse catalytic and regulatory biological processes and are
emerging as important disease biomarkers and therapeutic targets. Thus, develo** …

As the first intracellular host factors that directly interact with the genomes of RNA viruses,
RNA binding proteins (RBPs) have a profound impact on the outcome of an infection …

In recent years, mass spectrometry has emerged as a core component of fundamental
discoveries in virology. As a consequence of their coevolution, viruses and host cells have …

Hepatitis C virus (HCV) orchestrates the different stages of its life cycle in time and space
through the sequential participation of HCV proteins and cellular machineries; hence, these …

Every year, a major cause of human disease and death worldwide is infection with the
various pathogens—viruses, bacteria, fungi, and protozoa—that are intrinsic to our …

Viral quasispecies evolution upon long-term virus replication in a noncoevolving cellular
environment raises relevant general issues, such as the attainment of population …

Hepatitis C virus (HCV) is a major cause of liver disease worldwide. To establish and
maintain chronic infection, HCV extensively rearranges cellular organelles to generate …