Single-cell profiling methods have had a profound impact on the understanding of cellular
heterogeneity. While genomes and transcriptomes can be explored at the single-cell level …

Biotechnological innovations have vastly improved the capacity to perform large-scale
protein studies, while the methods we have for identifying and quantifying individual proteins …

The large size and complexity of most fern genomes have hampered efforts to elucidate
fundamental aspects of fern biology and land plant evolution through genome-enabled …

The sequencing of single protein molecules using nanopores is faced with a huge challenge
due to the lack of resolution needed to resolve single amino acids. Here we report the direct …

Nanopores are single-molecule sensors used in nucleic acid analysis, whereas their
applicability towards full protein identification has yet to be demonstrated. Here, we show …

The chemical nature and precise position of posttranslational modifications (PTMs) in
proteins or peptides are crucial for various severe diseases, such as cancer. State-of-the-art …

Structural complexity of glycans derived from the diversities in composition, linage,
configuration, and branching considerably complicates structural analysis. Nanopore-based …

Transmembrane β-barrels have considerable potential for a broad range of sensing
applications. Current engineering approaches for nanopore sensors are limited to naturally …

Protein post-translational modifications (PTMs) play a crucial role in countless biological
processes, profoundly modulating protein properties on both spatial and temporal scales …

Although nanopores can be used for single-molecule sequencing of nucleic acids using low-
cost portable devices, the characterization of proteins and their modifications has yet to be …