The traditional two-dimensional (2D) in vitro cell culture system (on a flat support) has long
been used in cancer research. However, this system cannot be fully translated into clinical …

Simple Summary For the research and development of drug discovery, it is of prime
importance to construct the three-dimensional (3D) tissue models in vitro. To this end, the …

The patient population suffering from pancreatic ductal adenocarcinoma (PDAC) presents,
as a whole, with a high degree of molecular tumor heterogeneity. The heterogeneity of …

Besides molecular and phenotypic variations observed in cancer cells, intratumoral
heterogeneity also occurs in the tumor microenvironment. Correlative stiffness maps of …

The mechanisms behind cancer initiation and progression are not clear. Therefore,
development of clinically relevant models to study cancer biology and drug response in …

The rational choice and design of biomaterials for biomedical applications is crucial for
successful in vitro and in vivo strategies, ultimately dictating their performance and potential …

Convenient and low-cost dressings can reduce the difficulty of wound treatment. Alginate gel
dressings have the advantages of low cost and safe usage, and they have obvious potential …

This review aims to show case recent regenerative medicine based on biomaterial
technologies. Regenerative medicine has arousing substantial interest throughout the world …

Over 90% of potential anti-cancer drug candidates results in translational failures in clinical
trials. The main reason for this failure can be attributed to the non-accurate pre-clinical …

With the aim of understanding and recapitulating cellular interactions of hepatocytes in their
physiological microenvironment and to generate an artificial 3D in vitro model, a co-culture …