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The evolution of neurofilament light chain in multiple sclerosis
Multiple sclerosis (MS) is an autoimmune, inflammatory neurodegenerative disease of the
central nervous system characterized by demyelination and axonal damage. Diagnosis and …
central nervous system characterized by demyelination and axonal damage. Diagnosis and …
N-Acetylaspartate in the CNS: from neurodiagnostics to neurobiology
The brain is unique among organs in many respects, including its mechanisms of lipid
synthesis and energy production. The nervous system-specific metabolite N-acetylaspartate …
synthesis and energy production. The nervous system-specific metabolite N-acetylaspartate …
Cortical demyelination and diffuse white matter injury in multiple sclerosis
A Kutzelnigg, CF Lucchinetti, C Stadelmann, W Brück… - Brain, 2005 - academic.oup.com
Focal demyelinated plaques in white matter, which are the hallmark of multiple sclerosis
pathology, only partially explain the patient's clinical deficits. We thus analysed global brain …
pathology, only partially explain the patient's clinical deficits. We thus analysed global brain …
Diffusion tensor imaging detects and differentiates axon and myelin degeneration in mouse optic nerve after retinal ischemia
Both axon and myelin degeneration have significant impact on the long-term disability of
patients with white matter disorder. However, the clinical manifestations of the neurological …
patients with white matter disorder. However, the clinical manifestations of the neurological …
Demyelination increases radial diffusivity in corpus callosum of mouse brain
Myelin damage, as seen in multiple sclerosis (MS) and other demyelinating diseases,
impairs axonal conduction and can also be associated with axonal degeneration. Accurate …
impairs axonal conduction and can also be associated with axonal degeneration. Accurate …
Pathology of multiple sclerosis and related inflammatory demyelinating diseases
This article provides a comprehensive overview of the pathology of multiple sclerosis (MS),
including recent insights into its molecular neuropathology and immunology. It shows that all …
including recent insights into its molecular neuropathology and immunology. It shows that all …
Gait and balance impairment in early multiple sclerosis in the absence of clinical disability
This study evaluated the gait and balance performance of two clinically distinct groups of
recently diagnosed and minimally impaired multiple sclerosis (MS) patients (Expanded …
recently diagnosed and minimally impaired multiple sclerosis (MS) patients (Expanded …
A basic overview of multiple sclerosis immunopathology
Multiple sclerosis (MS) is a multi‐component disease characterized by inflammation,
neurodegeneration and failure of central nervous system (CNS) repair mechanisms …
neurodegeneration and failure of central nervous system (CNS) repair mechanisms …
Axonal damage in relapsing multiple sclerosis is markedly reduced by natalizumab
M Gunnarsson, C Malmeström, M Axelsson… - Annals of …, 2011 - Wiley Online Library
Objective: The impact of present disease‐modifying treatments (DMTs) in multiple sclerosis
(MS) on nerve injury and reactive astrogliosis is still unclear. Therefore, we studied the effect …
(MS) on nerve injury and reactive astrogliosis is still unclear. Therefore, we studied the effect …
Evidence of early cortical atrophy in MS: relevance to white matter changes and disability
Objective: To assess cortical gray matter (GM) changes in MS and establish their relevance
to clinical disability and to inflammatory changes of white matter (WM) in patients with the …
to clinical disability and to inflammatory changes of white matter (WM) in patients with the …