Ageing is a complex process that negatively impacts the development of the immune system
and its ability to function. The mechanisms that underlie these age‐related defects are broad …

This report provides a review of early and late effects of radiation in normal tissues and
organs with respect to radiation protection. It was instigated following a recommendation in …

Following periods of haematopoietic cell stress, such as after chemotherapy, radiotherapy,
infection and transplantation, patient outcomes are linked to the degree of immune …

Abstract Interleukin-7 (IL-7) is required for T cell development and for maintaining and
restoring homeostasis of mature T cells. IL-7 is a limiting resource under normal conditions …

Allogeneic hematopoietic stem cell transplantation (HSCT) has evolved into an effective
adoptive cellular immunotherapy for the treatment of a number of cancers. The …

Chronic thymus involution associated with aging results in less efficient T-cell development
and decreased emigration of naïve T cells to the periphery. Thymic decline in the aged is …

Engineered T cell therapies have begun to demonstrate impressive clinical responses in
patients with B cell malignancies. Despite this efficacy, many patients are unable to receive …

Allogeneic hematopoietic stem cell transplantation (HSCT) has advanced to a common
procedure for treating also older patients with malignancies and immunodeficiency …

Aging is associated with decreased immune function that leads to increased morbidity and
mortality in the elderly. Immune senescence is accompanied by age-related changes in two …

The most profound consequences of immune senescence with respect to human health are
the increased susceptibility to infectious diseases and decreased vaccine efficacy. Changes …