Tissue imaging has become much more colourful in the past decade. Advances in both
experimental and analytical methods now make it possible to image protein markers in …

The proteome, or collection of proteoforms expressed in a biological system, is dynamic and
heterogeneous. As our appreciation for the complexity of the proteome has evolved, so have …

Mass spectrometry imaging (MSI) is a powerful tool for label-free map** of the spatial
distribution of proteins in biological tissues. We have previously demonstrated imaging of …

While technologies for multiplexed imaging have provided an unprecedented understanding
of tissue composition in health and disease, interpreting this data remains a significant …

Simple Summary Cell-to-cell variation exists within a population of the same cell type due to
stochastic gene and protein expression and environmental factors. Studying such cellular …

Quantitative methods for assessing neural anatomy have rapidly evolved in neuroscience
and provide important insights into brain health and function. However, as new techniques …

Neurodegenerative disorders are characterized by phenotypic changes and hallmark
proteopathies. Quantifying these in archival human brain tissues remains indispensable for …

Multiplexed ion beam imaging by time-of-flight (MIBI-TOF) is a form of mass spectrometry
imaging that uses metal labeled antibodies and secondary ion mass spectrometry to image …

Multiplex imaging platforms have enabled the identification of the spatial organization of
different types of cells in complex tissue or the tumor microenvironment. Exploring the …

Advances in single-cell proteomics technologies have resulted in high-dimensional datasets
comprising millions of cells that are capable of answering key questions about biology and …