The recent boom in microfluidics and combinatorial indexing strategies, combined with low
sequencing costs, has empowered single-cell sequencing technology. Thousands—or even …

Network medicine is an emerging area of research dealing with molecular and genetic
interactions, network biomarkers of disease, and therapeutic target discovery. Large-scale …

Abstract Background The Human Cell Atlas is a large international collaborative effort to
map all cell types of the human body. Single-cell RNA sequencing can generate high-quality …

Highlights•Interactive resource for bone marrow donor variation between cell
populations.•Deep evaluation of Human Cell Atlas (HCA) data spanning eight donors and …

Age-related changes to the genome-wide DNA methylation (DNAm) pattern observed in
blood are well-documented. Clonal hematopoiesis of indeterminate potential (CHIP) …

Single-cell multiomics technologies typically measure multiple types of molecule from the
same individual cell, enabling more profound biological insight than can be inferred by …

The genetic basis of human facial variation and craniofacial birth defects remains poorly
understood. Distant-acting transcriptional enhancers control the fine-tuned spatiotemporal …

A main goal of Precision Medicine is that of incorporating and integrating the vast corpora on
different databases about the molecular and environmental origins of disease, into analytic …

Recent developments in biomedical engineering have focused on designing smart and bio-
responsive materials. However, a critical step in designing this next generation of …

Abstract scRNA-seq dataset integration occurs in different contexts, such as the identification
of cell type-specific differences in gene expression across conditions or species, or batch …