The rise of antibiotic resistance and the decrease in the discovery of new antibiotics have
caused a global health crisis. Of particular concern is the fact that despite efforts to develop …

A significant advancement in the field of epigenetic drug discovery has been evidenced in
recent years. Epigenetic alterations are hereditary, nevertheless reversible variations to …

Abstract Histone deacetylase 8 (HDAC8) aberrantly deacetylates histone and non-histone
proteins. These include structural maintenance of chromosome 3 (SMC3) cohesin protein …

Histone deacetylases (HDACs) are crucial in gene transcription, removing acetyl groups
from histones. They also influence the deacetylation of non-histone proteins, contributing to …

Alzheimer disease (AD) is the most prevalent form of dementia that develops spontaneously
in the elderly. It's worth mentioning that as people age, the epigenetic profile of the central …

Apocynaceae, one of the largest plant families with over 5.100 widely distributed species,
serves as a significant model for evolutionary and biochemical studies. Within this family …

Histone deacetylase 3 (HDAC3) is a well-established target for cancer therapy. Herein, we
developed LSQ-28 as a novel HDAC3 inhibitor, which exhibited high HDAC3 inhibitory …

Background Belinostat, a histone deacetylase inhibitor used for hematological cancer
treatments, however, it caused thrombocytopenia, poor solubility, and rapid clearance. To …

Epigenetic changes play an important role in the pathophysiology of autoimmune diseases
such as allergic asthma, multiple sclerosis, lung diseases, diabetes, cystic fibrosis …

Introduction The synergistic combination of histone deacetylase inhibitors and platinum-
based medicines represents a promising therapeutic strategy to efficacy and overcome drug …