Lumbar disc degeneration is one of the leading causes of chronic low back pain. The
degenerative cascade is often initiated by an imbalance between catabolic and anabolic …

Degeneration of the intervertebral disc (IVD) is a normal part of aging. Due to the spine's
declining function and the development of pain, it may affect one's physical health, mental …

Low back pain (LBP) is a common disease that imposes a huge social and economic
burden on people. Intervertebral disc (IVD) degeneration (IVDD) is often considered to be …

With an aging population, there is a proportional increase in the prevalence of intervertebral
disc diseases. Intervertebral disc diseases are the leading cause of lower back pain and …

Intervertebral disc degeneration (IVDD) occurs as a result of an imbalance of the anabolic
and catabolic processes in the intervertebral disc, leading to an alteration in the composition …

Intervertebral disc (IVD) degeneration is a multifactorial pathological process associated
with low back pain, the leading cause of years lived in disability worldwide. Key …

Low back pain (LBP), frequently associated with intervertebral disc (IVD) degeneration, is a
major public health concern. LBP is currently managed by pharmacological treatments and …

Intervertebral disc degeneration (IVDD) is a multi-factorial process characterized by
phenotypic and genotypic changes, which leads to low back pain and disability. Prolonged …

Intervertebral disc (IVD) degeneration can cause chronic lower back pain (LBP), leading to
disability. Despite significant advances in the treatment of discogenic LBP, the limitations of …

Identifying genetic variants that influence human height will advance our understanding of
skeletal growth and development. Several rare genetic variants have been convincingly and …