Nrf2 regulates oxidative stress and its role in cerebral ischemic stroke
Cerebral ischemic stroke is characterized by acute ischemia in a certain part of the brain,
which leads to brain cells necrosis, apoptosis, ferroptosis, pyroptosis, etc. At present, there …
which leads to brain cells necrosis, apoptosis, ferroptosis, pyroptosis, etc. At present, there …
[HTML][HTML] Complex interplay between autophagy and oxidative stress in the development of pulmonary disease
The autophagic pathway involves the encapsulation of substrates in double-membraned
vesicles, which are subsequently delivered to the lysosome for enzymatic degradation and …
vesicles, which are subsequently delivered to the lysosome for enzymatic degradation and …
The protective role of exercise against age-related neurodegeneration
Endurance exercise is a widely accessible, low-cost intervention with a variety of benefits to
multiple organ systems. Exercise improves multiple indices of physical performance and …
multiple organ systems. Exercise improves multiple indices of physical performance and …
The functions and roles of sestrins in regulating human diseases
Y Chen, T Huang, Z Yu, Q Yu, Y Wang, J Hu… - Cellular & Molecular …, 2022 - Springer
Sestrins (Sesns), highly conserved stress-inducible metabolic proteins, are known to protect
organisms against various noxious stimuli including DNA damage, oxidative stress …
organisms against various noxious stimuli including DNA damage, oxidative stress …
Resveratrol attenuates hypoxia-induced neuronal cell death, inflammation and mitochondrial oxidative stress by modulation of TRPM2 channel
Hypoxia (HYPX) induced-overload Ca2+ entry results in increase of mitochondrial oxidative
stress, inflammation and apoptosis in several neurons. Ca2+ permeable TRPM2 channel …
stress, inflammation and apoptosis in several neurons. Ca2+ permeable TRPM2 channel …
Metabolic regulation of glia and their neuroinflammatory role in Alzheimer's disease
Alzheimer's disease (AD) is an aging-related neurodegenerative disorder. It is characterized
clinically by progressive memory loss and impaired cognitive function. Its progression occurs …
clinically by progressive memory loss and impaired cognitive function. Its progression occurs …
Cobalt induces neurodegenerative damages through impairing autophagic flux by activating hypoxia-inducible factor-1α triggered ROS overproduction
Cobalt is an environmental toxicant, and excessive bodily exposure can damage the
nervous system. Particularly, our previous study reported that low-dose cobalt (significantly …
nervous system. Particularly, our previous study reported that low-dose cobalt (significantly …
[HTML][HTML] Scutellarin acts on the AR-NOX axis to remediate oxidative stress injury in a mouse model of cerebral ischemia/reperfusion injury
M Deng, J Sun, L Peng, Y Huang, W Jiang, S Wu… - Phytomedicine, 2022 - Elsevier
Background Oxidative stress plays an important role in the pathology of ischemic stroke.
Studies have confirmedthat scutellarin has antioxidant effects against ischemic injury, and …
Studies have confirmedthat scutellarin has antioxidant effects against ischemic injury, and …
[HTML][HTML] Sprint Interval Training Improves Brain-Derived Neurotropic Factor-Induced Benefits in Brain Health—A Possible Molecular Signaling Intervention
Simple Summary Advances in exercise science have revealed how physical exercise
performance can help to shape our physiology. However, individual genetic traits, physical …
performance can help to shape our physiology. However, individual genetic traits, physical …
The interplay between oxidative stress and autophagy in chronic obstructive pulmonary disease
Autophagy is a highly conserved process that is indispensable for cell survival, embryonic
development, and tissue homeostasis. Activation of autophagy protects cells against …
development, and tissue homeostasis. Activation of autophagy protects cells against …