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Candidate biomarkers in psychiatric disorders: state of the field
The field of psychiatry is hampered by a lack of robust, reliable and valid biomarkers that can
aid in objectively diagnosing patients and providing individualized treatment …
aid in objectively diagnosing patients and providing individualized treatment …
Glutamatergic dysfunction in Schizophrenia
AO Kruse, JR Bustillo - Translational Psychiatry, 2022 - nature.com
The NMDA-R hypofunction model of schizophrenia started with the clinical observation of
the precipitation of psychotic symptoms in patients with schizophrenia exposed to PCP or …
the precipitation of psychotic symptoms in patients with schizophrenia exposed to PCP or …
Dopaminergic dysfunction and excitatory/inhibitory imbalance in treatment-resistant schizophrenia and novel neuromodulatory treatment
Antipsychotic drugs are the mainstay in the treatment of schizophrenia. However, one-third
of patients do not show adequate improvement in positive symptoms with non-clozapine …
of patients do not show adequate improvement in positive symptoms with non-clozapine …
Association of age, antipsychotic medication, and symptom severity in schizophrenia with proton magnetic resonance spectroscopy brain glutamate level: a mega …
Importance Proton magnetic resonance spectroscopy (1H-MRS) studies indicate that altered
brain glutamatergic function may be associated with the pathophysiology of schizophrenia …
brain glutamatergic function may be associated with the pathophysiology of schizophrenia …
Beyond antipsychotics: a twenty-first century update for preclinical development of schizophrenia therapeutics
Despite 50+ years of drug discovery, current antipsychotics have limited efficacy against
negative and cognitive symptoms of schizophrenia, and are ineffective—with the exception …
negative and cognitive symptoms of schizophrenia, and are ineffective—with the exception …
Variability and magnitude of brain glutamate levels in schizophrenia: a meta and mega-analysis
Glutamatergic dysfunction is implicated in schizophrenia pathoaetiology, but this may vary in
extent between patients. It is unclear whether inter-individual variability in glutamate is …
extent between patients. It is unclear whether inter-individual variability in glutamate is …
Insulin effects on core neurotransmitter pathways involved in schizophrenia neurobiology: a meta-analysis of preclinical studies. Implications for the treatment
Impairment of insulin action and metabolic dysregulation have traditionally been associated
with schizophrenia, although the molecular basis of such association remains still elusive …
with schizophrenia, although the molecular basis of such association remains still elusive …
Psychotic disorders as a framework for precision psychiatry
People with psychotic disorders can show marked interindividual variations in the onset of
illness, responses to treatment and relapse, but they receive broadly similar clinical care …
illness, responses to treatment and relapse, but they receive broadly similar clinical care …
[HTML][HTML] Neurofunctional correlates of glutamate and GABA imbalance in psychosis: A systematic review
Glutamatergic and GABAergic dysfunction are implicated in the pathophysiology of
schizophrenia. Previous work has shown relationships between glutamate, GABA, and brain …
schizophrenia. Previous work has shown relationships between glutamate, GABA, and brain …
[HTML][HTML] Exploring causal mechanisms of psychosis risk
Robust epidemiological evidence of risk and protective factors for psychosis is essential to
inform preventive interventions. Previous evidence syntheses have classified these risk and …
inform preventive interventions. Previous evidence syntheses have classified these risk and …