Transgenic animals are extensively used to study in vivo gene function as well as to model
human diseases. The technology for producing transgenic animals exists for a variety of …

Morpholino oligonucleotides (MOs) are an effective, gene-specific antisense knockdown
technology used in many model systems. Here we describe the application of MOs in …

Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated
(Cas) adaptive immune systems are found in bacteria and archaea to protect the hosts …

Background Customized zinc finger nucleases (ZFN s) form the basis of a broadly
applicable tool for highly efficient genome modification. ZFNs are artificial restriction …

Currently, only symptomatic therapy is available for Parkinson's disease. The zebrafish is a
vertebrate animal model ideally suited for high throughput compound screening to identify …

Zebrafish studies in the past two decades have made major contributions to our
understanding of hematopoiesis and its associated disorders. The zebrafish has proven to …

Abstract Introduction: Zebrafish (Danio rerio) is an ideal model organism for the study of
vertebrate development. This is due to the large clutches that each couple produces, with up …

In this review, we consider recent work using zebrafish to validate and study the functional
consequences of mutations of human genes implicated in a broad range of degenerative …

In the last two decades, zebrafish has become one of the fastest growing model organisms
in terms of publications, however it has been plagued with the absence of a key tool in the …

In 1868, Friedrich Miescher completed his medical training and joined the physiological
chemistry laboratory of Felix Hoppe-Seyler to study the chemical composition of biological …