Tubulin isotypes are known to regulate microtubule dynamic instability and contribute to the
development of drug resistance in certain types of cancers. Combretastatin-A4 (CA-4) has a …

The kinesin spindle protein (Eg5) is a mitotic protein that plays an essential role in the
formation of the bipolar spindles during the mitotic phase. Eg5 protein controls the …

Eg5 is a kinesin motor protein that is responsible for bipolar spindle formation and plays a
crucial role during mitosis. Loss of Eg5 function leads to the formation of monopolar …

Microtubules (MTs) play an essential role in mitosis; hence they are identified as potential
targets to design novel anti-mitotic agents. MT's are composed of α/β-tubulin isotypes that …

(+)-Morelloflavone (MF) is an antitumor biflavonoid that is found in the Garcinia species.
Recently, we reported MF as a novel inhibitor of ATPase and microtubules-gliding activities …

The hepatitis C virus (HCV)-infected population has continued to grow during recent years,
and novel HCV antiviral agents are urgently needed. In this work, a combined theoretical …

In search of achieving less toxic and more potent chemotherapeutics, three novel
heterocyclic benzimidazole derivatives: 2-(1H-benzo [d] imidazol-2-yl)-4-chlorophenol …

Abstract Heterobimetallic complexes [Cu (L) Sn (CH 3) 2 (H 2 O)(Cl)](3) and [Zn (L) Sn (CH
3) 2 (H 2 O)(Cl)](4) have been synthesized from their monometallic analogs [Cu (L)(H 2 …

Mitotic kinesin Eg5 remains a validated target in antimitotic therapy because of its essential
role in the formation and maintenance of bipolar mitotic spindles. Although numerous Eg5 …

The focus of this research is to investigate the effects of allostery on the function/activity of an
enzyme, human immunodeficiency virus type 1 (HIV-1) protease, using well-defined …