Recent advancements in flavonoid production through engineering microbial systems

Y Hwang, MH Noh, GY Jung - Biotechnology and Bioprocess Engineering, 2024‏ - Springer
Flavonoids are a class of polyphenolic compounds found in plants that offer extensive health
benefits and have applications in the pharmaceutical, cosmetic, and food industries …

[HTML][HTML] A model-driven approach to upcycling recalcitrant feedstocks in Pseudomonas putida by decoupling PHA production from nutrient limitation

MT Manoli, Á Gargantilla-Becerra… - Cell Reports, 2024‏ - cell.com
Bacterial polyhydroxyalkanoates (PHAs) have emerged as promising eco-friendly
alternatives to petroleum-based plastics since they are synthesized from renewable …

Production of γ-Aminobutyrate (GABA) in Recombinant Corynebacterium glutamicum by Expression of Glutamate Decarboxylase Active at Neutral pH

J Son, KA Baritugo, YJ Sohn, KH Kang, HT Kim… - ACS …, 2022‏ - ACS Publications
γ-Aminobutyrate (GABA) is an important chemical by itself and can be further used for the
production of monomer used for the synthesis of biodegradable polyamides. Until now …

Kinetic compartmentalization by unnatural reaction for itaconate production

D Ye, MH Noh, JH Moon, A Milito, M Kim… - Nature …, 2022‏ - nature.com
Physical compartmentalization of metabolism using membranous organelles in eukaryotes
is helpful for chemical biosynthesis to ensure the availability of substrates from competitive …

[HTML][HTML] Electric Stimulation of Astaxanthin Biosynthesis in Haematococcus pluvialis

HN Fitriana, SY Lee, SA Choi, JY Lee, BL Kim, JS Lee… - Applied Sciences, 2021‏ - mdpi.com
The green microalga Haematococcus pluvialis accumulates astaxanthin, a potent
antioxidant pigment, as a defense mechanism against environmental stresses. In this study …

Recent advances in the microbial production of C4 alcohols by metabolically engineered microorganisms

JI Yoo, YJ Sohn, J Son, SY Jo, J Pyo… - Biotechnology …, 2022‏ - Wiley Online Library
Background The heavy global dependence on petroleum‐based industries has led to
serious environmental problems, including climate change and global warming. As a result …

A tunable metabolic valve for precise growth control and increased product formation in Pseudomonas putida

C Batianis, RP van Rosmalen, M Major, C van Ee… - Metabolic …, 2023‏ - Elsevier
Metabolic engineering of microorganisms aims to design strains capable of producing
valuable compounds under relevant industrial conditions and in an economically …

DeepTESR: a deep learning framework to predict the degree of translational elongation short ramp for gene expression control

DJ Kim, J Kim, DH Lee, J Lee, HM Woo - ACS Synthetic Biology, 2022‏ - ACS Publications
Controlling translational elongation is essential for efficient protein synthesis. Ribosome
profiling has revealed that the speed of ribosome movement is correlated with translational …

Plug-in repressor library for precise regulation of metabolic flux in Escherichia coli

JY Lee, S Cha, JH Lee, HG Lim, MH Noh, CW Kang… - Metabolic …, 2021‏ - Elsevier
In metabolic engineering, enhanced production of value-added chemicals requires precise
flux control between growth-essential competing and production pathways. Although …

Microbial bioprocess for extracellular squalene production and formulation of nanoemulsions

J Park, DH Kang, HM Woo - ACS Sustainable Chemistry & …, 2021‏ - ACS Publications
Sustainable production of natural resources requires a clean manufacturing process with
clean raw materials due to the risk of environmental contaminations. Microbial cell factories …