Multifunctional mesoporous silica nanoparticles for biomedical applications

B Xu, S Li, R Shi, H Liu - Signal transduction and targeted therapy, 2023‏ - nature.com
Mesoporous silica nanoparticles (MSNs) are recognized as a prime example of
nanotechnology applied in the biomedical field, due to their easily tunable structure and …

Biofilm formation: mechanistic insights and therapeutic targets

X Wang, M Liu, C Yu, J Li, X Zhou - Molecular biomedicine, 2023‏ - Springer
Biofilms are complex multicellular communities formed by bacteria, and their extracellular
polymeric substances are observed as surface-attached or non-surface-attached …

Potentiating hypoxic microenvironment for antibiotic activation by photodynamic therapy to combat bacterial biofilm infections

W **u, L Wan, K Yang, X Li, L Yuwen, H Dong… - Nature …, 2022‏ - nature.com
Traditional antibiotic treatment has limited efficacy for the drug-tolerant bacteria present in
biofilms because of their unique metabolic conditions in the biofilm infection …

Biofilm heterogeneity-adaptive photoredox catalysis enables red light-triggered nitric oxide release for combating drug-resistant infections

J Cheng, G Gan, S Zheng, G Zhang, C Zhu… - Nature …, 2023‏ - nature.com
The formation of biofilms is closely associated with persistent and chronic infections, and
physiological heterogeneity such as pH and oxygen gradients renders biofilms highly …

A photo‐therapeutic nanocomposite with bio‐responsive oxygen self‐supplying combats biofilm infections and inflammation from drug‐resistant bacteria

Z Yuan, J Wu, Y **ao, H Yang, S Meng… - Advanced Functional …, 2023‏ - Wiley Online Library
The use of non‐antibiotic strategies to combat refractory drug‐resistant bacterial infections,
especially biofilms and accompanying inflammation, has recently aroused widespread …

An NIR‐II Photothermally Triggered “Oxygen Bomb” for Hypoxic Tumor Programmed Cascade Therapy

S Zhang, Z Li, Q Wang, Q Liu, W Yuan… - Advanced …, 2022‏ - Wiley Online Library
Hypoxia, as a characteristic feature of solid tumors, has a close relationship with tumor
resistance to photodynamic therapy (PDT) and chemotherapy. Perfluorocarbon (PFC) is …

Biomimetic electrodynamic nanoparticles comprising ginger-derived extracellular vesicles for synergistic anti-infective therapy

Z Qiao, K Zhang, J Liu, D Cheng, B Yu, N Zhao… - Nature …, 2022‏ - nature.com
Nanotechnology enlightens promising antibacterial strategies while the complex in vivo
infection environment poses a great challenge to the rational design of nanoplatforms for …

Nano–Bio Interactions: Biofilm‐Targeted Antibacterial Nanomaterials

B Li, J Mao, J Wu, K Mao, Y Jia, F Chen, J Liu - Small, 2024‏ - Wiley Online Library
Biofilm is a spatially organized community formed by the accumulation of both
microorganisms and their secretions, leading to persistent and chronic infections because of …

[HTML][HTML] Therapeutic strategies against bacterial biofilms

Y Bi, G **a, C Shi, J Wan, L Liu, Y Chen, Y Wu… - Fundamental …, 2021‏ - Elsevier
The emergence of multi-drug resistance makes bacterial infection a major threat to public
health and economy. The formation of bacterial biofilms is one of the main reasons of …

Artificial Phages with Biocatalytic Spikes for Synergistically Eradicating Antibiotic‐Resistant Biofilms

S **ao, L **e, Y Gao, M Wang, W Geng… - Advanced …, 2024‏ - Wiley Online Library
Antibiotic‐resistant pathogens have become a global public health crisis, especially biofilm‐
induced refractory infections. Efficient, safe, and biofilm microenvironment (BME)‐adaptive …