[HTML][HTML] Numerical approximations and convergence analysis of piecewise diffusion Markov processes, with application to glioma cell migration

E Buckwar, A Meddah - Applied Mathematics and Computation, 2025 - Elsevier
In this paper, we focus on numerical approximations of Piecewise Diffusion Markov
Processes (PDifMPs), particularly when the explicit flow maps are unavailable. Our …

Spatiotemporal dynamics of a glioma immune interaction model

S Khajanchi, JJ Nieto - Scientific Reports, 2021 - nature.com
We report a mathematical model which depicts the spatiotemporal dynamics of glioma cells,
macrophages, cytotoxic-T-lymphocytes, immuno-suppressive cytokine TGF-β and immuno …

Mathematical modeling of glioma invasion: acid-and vasculature mediated go-or-grow dichotomy and the influence of tissue anisotropy

M Conte, C Surulescu - Applied Mathematics and Computation, 2021 - Elsevier
Starting from kinetic transport equations and subcellular dynamics we deduce a multiscale
model for glioma invasion relying on the go-or-grow dichotomy and the influence of …

Mathematical modeling of glioma invasion and therapy approaches via kinetic theory of active particles

M Conte, Y Dzierma, S Knobe… - Mathematical Models and …, 2023 - World Scientific
A multiscale model for glioma spread in brain tissue under the influence of vascularization
and vascular endothelial growth factors is proposed. It accounts for the interplay between …

Modeling glioma invasion with anisotropy-and hypoxia-triggered motility enhancement: From subcellular dynamics to macroscopic PDEs with multiple taxis

G Corbin, A Klar, C Surulescu, C Engwer… - … Models and Methods …, 2021 - World Scientific
We deduce a model for glioma invasion that accounts for the dynamics of brain tissue being
actively degraded by tumor cells via excessive acidity production, but also according to the …

A kinetic derivation of spatial distributed models for tumor-immune system interactions

M Conte, R Travaglini - arxiv preprint arxiv:2410.17420, 2024 - arxiv.org
We propose a mathematical kinetic framework to investigate interactions between tumor
cells and the immune system, focusing on the spatial dynamics of tumor progression and …

Multi-cue kinetic model with non-local sensing for cell migration on a fiber network with chemotaxis

M Conte, N Loy - Bulletin of Mathematical Biology, 2022 - Springer
Cells perform directed motion in response to external stimuli that they detect by sensing the
environment with their membrane protrusions. Precisely, several biochemical and …

Estimating the extent of glioblastoma invasion: Approximate stationalization of anisotropic advection–diffusion–reaction equations in the context of glioblastoma …

C Engwer, M Wenske - Journal of Mathematical Biology, 2021 - Springer
Glioblastoma Multiforme is a malignant brain tumor with poor prognosis. There have been
numerous attempts to model the invasion of tumorous glioma cells via partial differential …

Go-or-Grow Models in Biology: a Monster on a Leash

R Thiessen, M Conte, TL Stepien, T Hillen - arxiv preprint arxiv …, 2024 - arxiv.org
Go-or-grow approaches represent a specific class of mathematical models used to describe
populations where individuals either migrate or reproduce, but not both simultaneously …

Multi-scale modeling of Snail-mediated response to hypoxia in tumor progression

G Chiari, M Conte, M Delitala - arxiv preprint arxiv:2404.16769, 2024 - arxiv.org
Tumor cell migration within the microenvironment is a crucial aspect for cancer progression
and, in this context, hypoxia has a significant role. An inadequate oxygen supply acts as an …