Myelin lipid metabolism and its role in myelination and myelin maintenance
JA Barnes-Vélez, FBA Yasar, J Hu - The Innovation, 2023 - cell.com
Myelin is a specialized cell membrane indispensable for rapid nerve conduction. The high
abundance of membrane lipids is one of myelin's salient features that contribute to its unique …
abundance of membrane lipids is one of myelin's salient features that contribute to its unique …
Lipids shape brain function through ion channel and receptor modulations: physiological mechanisms and clinical perspectives
Lipids represent the most abundant molecular type in the brain, with a fat content of∼ 60%
of the dry brain weight in humans. Despite this fact, little attention has been paid to …
of the dry brain weight in humans. Despite this fact, little attention has been paid to …
PMP22 duplication dysregulates lipid homeostasis and plasma membrane organization in develo** human Schwann cells
R Prior, A Silva, T Vangansewinkel, J Idkowiak… - Brain, 2024 - academic.oup.com
Abstract Charcot–Marie–Tooth disease type 1A (CMT1A) is the most common inherited
peripheral neuropathy caused by a 1.5 Mb tandem duplication of chromosome 17 …
peripheral neuropathy caused by a 1.5 Mb tandem duplication of chromosome 17 …
[HTML][HTML] Mechanisms and treatments in demyelinating CMT
Abstract Demyelinating forms of Charcot-Marie-Tooth disease (CMT) are genetically and
phenotypically heterogeneous and result from highly diverse biological mechanisms …
phenotypically heterogeneous and result from highly diverse biological mechanisms …
Treating PMP22 gene duplication-related Charcot-Marie-Tooth disease: the past, the present and the future
Charcot-Marie-Tooth (CMT) disease is the most frequent inherited neuropathy, affecting
1/1500 to 1/10000. CMT1A represents 60%-70% of all CMT and is caused by a duplication …
1/1500 to 1/10000. CMT1A represents 60%-70% of all CMT and is caused by a duplication …
Mechanisms and treatment strategies of demyelinating and dysmyelinating Charcot-Marie-Tooth disease
Schwann cells, the myelinating glia of the peripheral nervous system, wrap axons multiple
times to build their myelin sheath. Myelin is of paramount importance for axonal integrity and …
times to build their myelin sheath. Myelin is of paramount importance for axonal integrity and …
The role of the ATP-binding cassette A1 (ABCA1) in neurological disorders: a mechanistic review
T Paseban, MS Alavi, L Etemad… - Expert Opinion on …, 2023 - Taylor & Francis
Introduction Cholesterol homeostasis is critical for normal brain function. It is tightly
controlled by various biological elements. ATP-binding cassette transporter A1 (ABCA1) is a …
controlled by various biological elements. ATP-binding cassette transporter A1 (ABCA1) is a …
Ion mobility–mass spectrometry reveals the role of peripheral myelin protein dimers in peripheral neuropathy
Peripheral myelin protein (PMP22) is an integral membrane protein that traffics inefficiently
even in wild-type (WT) form, with only 20% of the WT protein reaching its final plasma …
even in wild-type (WT) form, with only 20% of the WT protein reaching its final plasma …
Dysregulated miR-29a-3p/PMP22 modulates Schwann cell proliferation and migration during peripheral nerve regeneration
Y Shen, Z Cheng, S Chen, Y Zhang, Q Chen… - Molecular …, 2022 - Springer
Schwann cells switch to a repair phenotype following peripheral nerve injury and create a
favorable microenvironment to drive nerve repair. Many microRNAs (miRNAs) are …
favorable microenvironment to drive nerve repair. Many microRNAs (miRNAs) are …
A novel histone deacetylase 6 inhibitor improves myelination of Schwann cells in a model of Charcot–Marie–Tooth disease type 1A
N Ha, YI Choi, N Jung, JY Song, DK Bae… - British journal of …, 2020 - Wiley Online Library
Background and Purpose Charcot–Marie–Tooth (CMT) disease is the most common
hereditary peripheral neuropathy. CMT type 1A (CMT1A) accounts for approximately 50% of …
hereditary peripheral neuropathy. CMT type 1A (CMT1A) accounts for approximately 50% of …