Mitochondria are intracellular organelles involved in energy production, cell metabolism and
cell signaling. They are essential not only in the process of ATP synthesis, lipid metabolism …

NAD+ was discovered during yeast fermentation, and since its discovery, its important roles
in redox metabolism, aging, and longevity, the immune system and DNA repair have been …

Cancer cells continuously rewire their metabolism to fulfill their need for rapid growth and
survival while subject to changes in environmental cues. Thus, a vital component of a cancer …

Autophagy and mitophagy act in cancer as bimodal processes, whose differential functions
strictly depend on cancer ontogenesis, progression, and type. For instance, they can act to …

In contrast to terminally differentiated cells, cancer cells and stem cells retain the ability to re-
enter the cell cycle and proliferate. To proliferate, cells must increase their uptake and …

The rediscovery and reinterpretation of the Warburg effect in the year 2000 occulted for
almost a decade the key functions exerted by mitochondria in cancer cells. Until recent …

The term “cancer stem cell”(CSC) refers to a cancer cell with the following features:
clonogenic ability, the expression of stem cell markers, differentiation into cells of different …

Depending on their tissue of origin, genetic and epigenetic marks and microenvironmental
influences, cancer cells cover a broad range of metabolic activities that fluctuate over time …

Malignant stem cells have long been considered a key therapeutic target in leukemia.
Therapeutic strategies designed to target the fundamental biology of leukemia stem cells …

Background Mitophagy refers to the selective self‐elimination of mitochondria under
damaged or certain developmental conditions. As an important regulatory mechanism to …